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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 938574, 7 pages
http://dx.doi.org/10.1155/2012/938574
Review Article

The Effects of Tualang Honey on Bone Metabolism of Postmenopausal Women

Department of Pharmacology, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur Campus, 50300 Kuala Lumpur, Malaysia

Received 7 June 2012; Revised 19 July 2012; Accepted 1 August 2012

Academic Editor: Srijit Das

Copyright © 2012 Nadia Mohd Effendy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. WHO, Traditional Medicine, WHO, Geneva, Switzerland, 2003.
  2. WHO, Traditional Medicine, WHO Congress, Beijing, China, 2008.
  3. J. H. Thrall, “Prevalence and costs of chronic disease in a health care system structured for treatment of acute illness,” Radiology, vol. 235, no. 1, pp. 9–12, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Christiansen, “Consensus Development Conference: prophylaxis and treatment of osteoporosis,” American Journal of Medicine, vol. 90, no. 1, pp. 107–110, 1991. View at Publisher · View at Google Scholar · View at Scopus
  5. National Osteoporosis Foundation, Prevalence Report, Washington, DC, USA, 2010.
  6. J. P. Bilezikian, “Osteoporosis in men,” Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 10, pp. 3431–3434, 1999. View at Google Scholar · View at Scopus
  7. E. Gielen, D. Vanderschueren, F. Callewaert, and S. Boonen, “Osteoporosis in men,” Best Practice and Research, vol. 25, no. 2, pp. 321–335, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Lauralee, Fundamentals of Physiology: A Human Perspective, Brooks/Coe Cengage Learning, Ontario, Canada, 4th edition, 2011.
  9. F. Callewaert, S. Boonen, and D. Vanderschueren, “Sex steroids and the male skeleton: a tale of two hormones,” Trends in Endocrinology and Metabolism, vol. 21, no. 2, pp. 89–95, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Legrand, C. Hedde, Y. Gallois et al., “Osteoporosis in men: a potential role for the sex hormone binding globulin,” Bone, vol. 29, no. 1, pp. 90–95, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. N. F. Ray, J. K. Chan, M. Thamer, and L. J. Melton III, “Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation,” Journal of Bone and Mineral Research, vol. 12, no. 1, pp. 24–35, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. E. S. Orwoll, “Osteoporosis in men,” Endocrinology and Metabolism Clinics of North America, vol. 27, no. 2, pp. 349–367, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. V. Gilsanz, “Accumulation of bone mass during childhood and adolescence,” in Osteoporosis in Men, E. S. Orwoll, Ed., pp. 65–68, Academic Press, San Diego, Calif, USA, 2nd edition, 1999. View at Google Scholar
  14. A. R. Rodney and R. B. David, Medical Physiology: Principles for Clinical Medicine, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 4th edition, 2001.
  15. S. Boonen, J. J. Body, Y. Boutsen et al., “Evidence-based guidelines for the treatment of postmenopausal osteoporosis: a consensus document of the Belgian Bone Club,” Osteoporosis International, vol. 16, no. 3, pp. 239–254, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. D. J. Torgerson and S. E. M. Bell-Syer, “Hormone replacement therapy and prevention of nonvertebral fractures: a meta-analysis of randomized trials,” Journal of the American Medical Association, vol. 285, no. 22, pp. 2891–2897, 2001. View at Google Scholar · View at Scopus
  17. C. Schairer, J. Lubin, R. Troisi, S. Sturgeon, L. Brinton, and R. Hoover, “Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk,” Journal of the American Medical Association, vol. 283, no. 4, pp. 485–491, 2000. View at Google Scholar · View at Scopus
  18. R. J. Santen, J. Pinkerton, C. McCartney, and G. R. Petroni, “Clinical review 121: risk of breast cancer with progestins in combination with estrogen as hormone replacement therapy,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 1, pp. 16–23, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. Collaborative Group on Hormonal Factors for Breast Cancer, “Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer,” The Lancet, vol. 350, no. 9084, pp. 1047–1059, 1997. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Reiner, F. Bertha, V. T. Emmo, and B. Christoph, Biphosphonates in Medical Practice, Springer, New York, USA, 2007.
  21. R. Makins and A. Ballinger, “Gastrointestinal side effects of drugs,” Expert Opinion on Drug Safety, vol. 2, no. 4, pp. 421–429, 2003. View at Google Scholar · View at Scopus
  22. S. Khosla, D. Burr, J. Cauley et al., “Bisphosphonate-associated osteonecrosis of the jaw: report of a Task Force of the American Society for Bone and Mineral Research,” Journal of Bone and Mineral Research, vol. 22, no. 10, pp. 1479–1491, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. P. C. Molan, “Why honey is effective as a medicine. I. Its use in modern medicine,” Bee World, vol. 80, no. 2, pp. 80–92, 1999. View at Google Scholar · View at Scopus
  24. E. Crane, “History of honey,” in Honey, A Comprehensive Survey, E. Crane, Ed., pp. 439–388, William Heiemann, London, UK, 1975. View at Google Scholar
  25. R. Jones, “Honey and healing through ages,” in Honey and Healing, P. Munn and R. Jones, Eds., pp. 1–4, Cardiff: International Bee Research Association IBRA, 2001. View at Google Scholar
  26. A. J. Van den Berg, E. van den Worm, H. C. Van Ufford, S. B. Halkes, M. J. Hoekstra, and C. J. Beukelman, “An in vitro examination of the antioxidant and anti-inflammatory properties of buckwheat honey,” Journal of Wound Care, vol. 17, no. 4, pp. 172–178, 2008. View at Google Scholar · View at Scopus
  27. P. C. Molan, “The evidence supporting the use of honey as a wound dressing,” International Journal of Lower Extremity Wounds, vol. 5, no. 1, pp. 40–54, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. O. O. Erejuwa, S. Gurtu, S. A. Sulaiman, M. S. A. Wahab, K. N. S. Sirajudeen, and M. S. Salleh, “Hypoglycemic and antioxidant effects of honey supplementation in streptozotocin-induced diabetic rats,” International Journal for Vitamin and Nutrition Research, vol. 80, no. 1, pp. 74–82, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Kassim, M. Achoui, M. R. Mustafa, M. A. Mohd, and K. M. Yusoff, “Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity,” Nutrition Research, vol. 30, no. 9, pp. 650–659, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. O. O. Erejuwa, S. A. Sulaiman, and M. S. Wahab, “Fructose might contribute to the hypoglycaemic effect of honey,” Molecules, vol. 17, no. 2, pp. 1900–1915, 2012. View at Google Scholar
  31. S. Bogdanov, T. Jurendic, R. Sieber, and P. Gallmann, “Honey for nutrition and health: a review,” Journal of the American College of Nutrition, vol. 27, no. 6, pp. 677–689, 2008. View at Google Scholar · View at Scopus
  32. M. Al-Mamary, A. Al-Meeri, and M. Al-Habori, “Antioxidant activities and total phenolics of different types of honey,” Nutrition Research, vol. 22, no. 9, pp. 1041–1047, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. A. R. Pérez, M. T. Iglesias, E. Pueyo, M. González, and C. de Lorenzo, “Amino acid composition and antioxidant capacity of Spanish honeys,” Journal of Agricultural and Food Chemistry, vol. 55, no. 2, pp. 360–365, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Z. Mat Saad, W. S. Wan Azman, S. H. Ahmad, Y. S. Mohd, and H. Jaafar, “The efficacy of Tualang honey in comparison to silver dressing wounds in rats,” Journal of ApiProduct and ApiMedical Science, vol. 3, no. 1, pp. 45–53, 2011. View at Google Scholar
  35. D. M. Yasotha, E. O. Chin, A. S. Siti, C. T. Soo, and I. Rusli, “In vitro inhibitory effect of Tualang honey on cytochrome P450 2C8 activity,” Journal of Pharmacy and Pharmacology, pp. 1–9, 2012. View at Google Scholar
  36. G. Beretta, M. Orioli, and R. M. Facino, “Antioxidant and radical scavenging activity of honey in endothelial cell cultures (EA.hy926),” Planta Medica, vol. 73, no. 11, pp. 1182–1189, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. P. A. Hill, “Bone remodelling,” British Journal of Orthodontics, vol. 25, no. 2, pp. 101–107, 1998. View at Google Scholar · View at Scopus
  38. S. Srivastava, G. Toraldo, M. N. Weitzmann, S. Cenci, F. P. Ross, and R. Pacifici, “Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-κB ligand (RANKL)-induced JNK activation,” Journal of Biological Chemistry, vol. 276, no. 12, pp. 8836–8840, 2001. View at Publisher · View at Google Scholar · View at Scopus
  39. G. Eghbali-Fatourechi, S. Khosla, A. Sanyal, W. J. Boyle, D. L. Lacey, and B. L. Riggs, “Role of RANK ligand in mediating increased bone resorption in early postmenopausal women,” Journal of Clinical Investigation, vol. 111, no. 8, pp. 1221–1230, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. L. C. Hofbauer, S. Khosla, C. R. Dunstan, D. L. Lacey, T. C. Spelsberg, and B. L. Riggs, “Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells,” Endocrinology, vol. 140, no. 9, pp. 4367–4370, 1999. View at Google Scholar · View at Scopus
  41. M. Badeau, H. Adlercreutz, P. Kaihovaara, and M. J. Tikkanen, “Estrogen A-ring structure and antioxidative effect on lipoproteins,” Journal of Steroid Biochemistry and Molecular Biology, vol. 96, no. 3-4, pp. 271–278, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. E. Amir, O. C. Freedman, B. Seruga, and D. G. Evans, “Assessing women at high risk of breast cancer: a review of risk assessment models,” Journal of the National Cancer Institute, vol. 102, no. 10, pp. 680–691, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. D. Maggio, M. Barabani, M. Pierandrei et al., “Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 4, pp. 1523–1527, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Almeida, L. Han, M. Martin-Millan et al., “Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids,” Journal of Biological Chemistry, vol. 282, no. 37, pp. 27285–27297, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. W. Fabien, L. Laurent, C. Veronique, G. Jerome, and W. Yohann, “Oxidative stress in bone remodelling and disease,” Trends in Molecular Medicine, vol. 15, no. 10, pp. 468–477, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. N. Mody, F. Parhami, T. A. Sarafian, and L. L. Demer, “Oxidative stress modulates osteoblastic differentiation of vascular and bone cells,” Free Radical Biology and Medicine, vol. 31, no. 4, pp. 509–519, 2001. View at Publisher · View at Google Scholar · View at Scopus
  47. X. C. Bai, D. Lu, J. Bai et al., “Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-κB,” Biochemical and Biophysical Research Communications, vol. 314, no. 1, pp. 197–207, 2004. View at Publisher · View at Google Scholar · View at Scopus
  48. O. Salih, K. Huseyin, F. Ersin, A. Rabia, and Y. Zumrut, “Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis,” Molecular and Cellular Biochemistry, vol. 295, no. 1-2, pp. 45–52, 2007. View at Publisher · View at Google Scholar · View at Scopus
  49. R. J. Van'T Hof and S. H. Ralston, “Cytokine-induced nitric oxide inhibits bone resorption by inducing apoptosis of osteoclast progenitors and suppressing osteoclast activity,” Journal of Bone and Mineral Research, vol. 12, no. 11, pp. 1797–1804, 1997. View at Google Scholar · View at Scopus
  50. S. H. Ralston, D. Todd, M. Helfrich, N. Benjamin, and P. S. Grabowski, “Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase,” Endocrinology, vol. 135, no. 1, pp. 330–336, 1994. View at Publisher · View at Google Scholar · View at Scopus
  51. H. MacPherson and S. H. Ralston, “Expression and functional role of nitric oxide synthase isoforms in human osteoblast-like cells,” Bone, vol. 24, no. 3, pp. 179–185, 1999. View at Publisher · View at Google Scholar · View at Scopus
  52. P. Ammann, R. Rizzoli, D. Slosman, and J. P. Bonjour, “Sequential and precise in vivo measurement of bone mineral density in rats using dual-energy x-ray absorptiometry,” Journal of Bone and Mineral Research, vol. 7, no. 3, pp. 311–316, 1992. View at Google Scholar · View at Scopus
  53. D. N. Kalu, “The ovariectomized rat model of postmenopausal bone loss,” Bone and Mineral, vol. 15, no. 3, pp. 175–191, 1991. View at Publisher · View at Google Scholar · View at Scopus
  54. S. Muthusami, I. Ramachandran, B. Muthusamy et al., “Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats,” Clinica Chimica Acta, vol. 360, no. 1-2, pp. 81–86, 2005. View at Publisher · View at Google Scholar · View at Scopus
  55. B. Halliwell and J. M. C. Gutteridge, Free Radicals in Biology and Medicine, Clarendon Press, Oxford, UK, 2007.
  56. B. Halliwell, “Free radicals and antioxidants—quo vadis?” Trends in Pharmacological Sciences, vol. 32, no. 3, pp. 125–130, 2011. View at Publisher · View at Google Scholar · View at Scopus
  57. A. S. Nazrun, M. Norazlina, M. Norliza, and S. I. Nirwana, “The anti-inflammatory role of vitamin E in prevention of osteoporosis,” Advance in Pharmacological Sciences, vol. 2012, Article ID 142702, pp. 1–7, 2012. View at Publisher · View at Google Scholar
  58. M. E. Nadia, A. S. Nazrun, M. Norazlina, N. M. Isa, M. Norliza, and S. Ima Nirwana, “The anti-inflammatory, phytoestrogenic and antioxidative role of Labisia pumila in prevention of postmenopausal osteoporosis,” Advances in Pharmacological Sciences, vol. 2012, Article ID 706905, 7 pages, 2012. View at Publisher · View at Google Scholar
  59. M. Mohamed, K. N. S. Sirajudeen, M. Swamy, N. S. Yaacob, and S. A. Sulaiman, “Studies on the antioxidant properties of tualang honey of Malaysia,” African Journal of Traditional, Complementary and Alternative Medicines, vol. 7, no. 1, pp. 59–63, 2010. View at Google Scholar · View at Scopus
  60. R. K. Kishore, A. S. Halim, M. S. N. Syazana, and K. N. S. Sirajudeen, “Tualang honey has higher phenolic content and greater radical scavenging activity compared with other honey sources,” Nutrition Research, vol. 31, no. 4, pp. 322–325, 2011. View at Publisher · View at Google Scholar · View at Scopus
  61. S. S. M. Zaid, S. A. Sulaiman, K. N. M. Sirajudeen, and N. H. Othman, “The effects of tualang honey on female reproductive organs, tibia bone and hormonal profile in ovariectomised rats—animal model for menopause,” BMC Complementary and Alternative Medicine, vol. 10, article 82, 2010. View at Publisher · View at Google Scholar · View at Scopus
  62. S. K. Jaganathan and M. Mandal, “Antiproliferative effects of honey and of its polyphenols: a review,” Journal of Biomedicine and Biotechnology, vol. 2009, Article ID 830616, 13 pages, 2009. View at Publisher · View at Google Scholar · View at Scopus
  63. S. Buratti, S. Benedetti, and M. S. Cosio, “Evaluation of the antioxidant power of honey, propolis and royal jelly by amperometric flow injection analysis,” Talanta, vol. 71, no. 3, pp. 1387–1392, 2007. View at Publisher · View at Google Scholar · View at Scopus
  64. S. Z. Hussein, K. M. Yusoff, S. Makpol, and Y. A. Yusof, “Antioxidant capacities and total phenolic contents increase with gamma irradiation in two types of Malaysian honey,” Molecules, vol. 16, no. 8, pp. 6378–6395, 2011. View at Google Scholar
  65. A. Wattel, S. Kamel, R. Mentaverri et al., “Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption,” Biochemical Pharmacology, vol. 65, no. 1, pp. 35–42, 2003. View at Publisher · View at Google Scholar · View at Scopus
  66. A. Wattel, S. Kamel, C. Prouillet et al., “Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NFκB and AP-1,” Journal of Cellular Biochemistry, vol. 92, no. 2, pp. 285–295, 2004. View at Publisher · View at Google Scholar · View at Scopus
  67. Y. O. Son, S. H. Kook, K. C. Choi et al., “Quercetin, a bioflavonoid, accelerates TNF-α-induced growth inhibition and apoptosis in MC3T3-E1 osteoblastic cells,” European Journal of Pharmacology, vol. 529, no. 1–3, pp. 24–32, 2006. View at Publisher · View at Google Scholar · View at Scopus
  68. J. L. Pang, D. A. Ricupero, S. Huang et al., “Differential activity of kaempferol and quercetin in attenuating tumor necrosis factor receptor family signaling in bone cells,” Biochemical Pharmacology, vol. 71, no. 6, pp. 818–826, 2006. View at Publisher · View at Google Scholar · View at Scopus
  69. J. González-Gallego, S. Sánchez-Campos, and M. J. Tuñón, “Anti-inflammatory properties of dietary flavonoids,” Nutricion Hospitalaria, vol. 22, no. 3, pp. 287–293, 2007. View at Google Scholar · View at Scopus
  70. G. R. Mundy, “Osteoporosis and inflammation,” Nutrition Reviews, vol. 65, no. 12, pp. S147–151, 2007. View at Google Scholar · View at Scopus
  71. K. Ishihara and T. Hirano, “IL-6 in autoimmune disease and chronic inflammatory proliferative disease,” Cytokine and Growth Factor Reviews, vol. 13, no. 4-5, pp. 357–368, 2002. View at Publisher · View at Google Scholar · View at Scopus
  72. J. H. Francis, D. K. Lee, V.J.H Mik, A. O'Donnell, M. Jacques, and M. P. Julia, “Cytokine-induced prostaglandin E2 synthesis and cyclooxygenase-2 activity are regulated both by a nitric oxide-dependent and -independent mechanism in rat osteoblasts in vitro,” Journal of Biological Chemistry, vol. 274, no. 3, pp. 1776–1782, 1999. View at Publisher · View at Google Scholar · View at Scopus
  73. S. V. Reddy and G. D. Roodman, “Control of osteoclast differentiation,” Critical Reviews in Eukaryotic Gene Expression, vol. 8, no. 1, pp. 1–17, 1998. View at Google Scholar · View at Scopus
  74. R. Pacifici, C. Brown, E. Puscheck et al., “Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 88, no. 12, pp. 5134–5138, 1991. View at Publisher · View at Google Scholar · View at Scopus
  75. G. R. Mundy, “Osteoporosis and inflammation,” Nutrition Reviews, vol. 65, no. 12, pp. S147–151, 2007. View at Google Scholar · View at Scopus
  76. Y. Ishimi, C. Miyaura, C. H. Jin et al., “IL-6 is produced by osteoblasts and induces bone resorption,” The Journal of Immunology, vol. 145, no. 10, pp. 3297–3303, 1990. View at Google Scholar · View at Scopus
  77. R. L. Jilka, “Cytokines, bone remodeling, and estrogen deficiency: a 1998 update,” Bone, vol. 23, no. 2, pp. 75–81, 1998. View at Publisher · View at Google Scholar · View at Scopus
  78. L. C. Hofbauer, S. Khosla, C. R. Dunstan, D. L. Lacey, T. C. Spelsberg, and B. L. Riggs, “Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells,” Endocrinology, vol. 140, no. 9, pp. 4367–4370, 1999. View at Google Scholar · View at Scopus
  79. R. B. Kimble, A. B. Matayoshi, J. L. Vannice, V. T. Kung, C. Williams, and R. Pacifici, “Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period,” Endocrinology, vol. 136, no. 7, pp. 3054–3061, 1995. View at Google Scholar · View at Scopus
  80. G. Girasole, G. Passeri, R. L. Jilka, and S. C. Manolagas, “Interleukin-11: a new cytokine critical for osteoclast development,” Journal of Clinical Investigation, vol. 93, no. 4, pp. 1516–1524, 1994. View at Google Scholar · View at Scopus
  81. N. S. Al-Waili and N. S. Boni, “Natural honey lowers plasma prostaglandin concentrations in normal individuals,” Journal of Medicinal Food, vol. 6, no. 2, pp. 129–133, 2003. View at Google Scholar · View at Scopus
  82. B. V. Owoyele, O. T. Adenekan, and A. O. Soladoye, “Effects of honey on inflammation and nitric oxide production in Wistar rats,” Journal of Chinese Integrative Medicine, vol. 9, no. 4, pp. 447–452, 2011. View at Publisher · View at Google Scholar · View at Scopus
  83. H. Lily, N. H. Nik Hazlina, S. Siti Amrah et al., “The effects of Tualang honey on postmenopausal women,” in Proceedings of the 2nd International Conference on the Medicinal Use of Honey, vol. 2 of Journal of ApiProduct and ApiMedical Science, no. 1, pp. 31–60, Kota Bharu, Malaysia, 2010.
  84. C. G. Farid, “Morphological characterization study of Malaysian honey—a VPSEM, EDX Randomised attempt,” Annals of Microscopy, vol. 9, pp. 93–100, 2009. View at Google Scholar
  85. M. W. Ariefdjohan, B. R. Martin, P. J. Lachcik, and C. M. Weaver, “Acute and chronic effects of honey and its carbohydrate constituents on calcium absorption in rats,” Journal of Agricultural and Food Chemistry, vol. 56, no. 8, pp. 2649–2654, 2008. View at Publisher · View at Google Scholar · View at Scopus
  86. S. Bogdanov, T. Jurendic, R. Sieber, and P. Gallmann, “Honey for nutrition and health: a review,” Journal of the American College of Nutrition, vol. 27, no. 6, pp. 677–689, 2008. View at Google Scholar · View at Scopus
  87. O. O. Erejuwa, S. A. Sulaiman, M. S. Wahab, K. N. S. Sirajudeen, M. S. Salleh, and S. Gurtu, “Hepatoprotective effect of Tualang honey supplementation in streptozotocin-induced diaibetic rats,” International Journal of Applied Research in Natural Products, vol. 4, no. 4, pp. 37–41, 2012. View at Google Scholar
  88. F. H. Paul and S. Joann, Drug Metabolism Handbook: Concepts and Applications, John Wiley & Sons, New Jersey, NJ, USA, 2009.