3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus
Figure 1
Effects of orally administrated oseltamivir phosphate, PWE, PEE, 3,4-diCQA, and chlorogenic acid on the body weight of BALB/c mice infected with the IAV. (a) control (⚫), oseltamivir (0.5 mg/kg; ■), 3,4-diCQA (50 mg/kg; ◆), (b) PWE (100 mg/kg; ▲), PEE (100 mg/kg; ▾), or chlorogenic acid (50 mg/kg; ⚫) was administrated twice daily starting at 4 hours before the first viral infection until 5 days postinfection (5 dpi). The data represent the mean ± SE for the mice that survived. *< 0.05 and **< 0.01 versus vehicle control.
