3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus
Table 1
Survival of mice infected with IAV after the oral administration of various substances.
Treatment
n
Dose
Duration (dpi)
Survival time (dpi, mean ± SE)
Statistical significance
5% Arabic gum
9
0–5
7.4 ± 0.7
oseltamivir
8
0.5 mg twice/kg/day
0–5
>12.0 #
**
PWE
9
100 mg twice/kg/day
0–5
10.0 ± 0.9
*
PEE
9
100 mg twice/kg/day
0–5
10.1 ± 0.9
*
3,4-diCQA
7
50 mg twice/kg/day
0–5
10.3 ± 1.5
*
Chlorogenic acid
9
50 mg twice/kg/day
0–5
8.1 ± 0.8
N.S.
#standard error not determined; * < 0.05; ** < 0.01; N.S. not significant.
