Antiallodynic Effect of Herbal Medicine Yokukansan on Peripheral Neuropathy in Rats with Chronic Constriction Injury

Figure 4

Effect of glutamate transporter inhibitors on the anti-allodynic effects of yokukansan on mechanical (a) or cold (b) stimulation with a von Frey filament or acetone in CCI rats. A glutamate transporter inhibitor, TBHA (1 μg) or DHK (5 mM), was simultaneously intrathecally injected when yokukansan (1.0 g/kg) was orally administered. Differences between values before and 1 hour after yokukansan administration are expressed as the mean ± standard error. *𝑃<0.05, **𝑃<0.01 versus yokukansan alone (Dunnett’s t-test).

(a)

(b)