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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 954374, 9 pages
http://dx.doi.org/10.1155/2012/954374
Research Article

Testing Homeopathy in Mouse Emotional Response Models: Pooled Data Analysis of Two Series of Studies

1Department of Pathology and Diagnostics, University of Verona, 37134 Verona, Italy
2Department of Public Health and Community Medicine, University of Verona, 37134 Verona, Italy

Received 21 November 2011; Accepted 29 January 2012

Academic Editor: Carlo Ventura

Copyright © 2012 Paolo Bellavite et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two previous investigations were performed to assess the activity of Gelsemium sempervirens (Gelsemium s.) in mice, using emotional response models. These two series are pooled and analysed here. Gelsemium s. in various homeopathic centesimal dilutions/dynamizations (4C, 5C, 7C, 9C, and 30C), a placebo (solvent vehicle), and the reference drugs diazepam (1 mg/kg body weight) or buspirone (5 mg/kg body weight) were delivered intraperitoneally to groups of albino CD1 mice, and their effects on animal behaviour were assessed by the light-dark (LD) choice test and the open-field (OF) exploration test. Up to 14 separate replications were carried out in fully blind and randomised conditions. Pooled analysis demonstrated highly significant effects of Gelsemium s. 5C, 7C, and 30C on the OF parameter “time spent in central area” and of Gelsemium s. 5C, 9C, and 30C on the LD parameters “time spent in lit area” and “number of light-dark transitions,” without any sedative action or adverse effects on locomotion. This pooled data analysis confirms and reinforces the evidence that Gelsemium s. regulates emotional responses and behaviour of laboratory mice in a nonlinear fashion with dilution/dynamization.