Astragaloside IV Downregulates β-Catenin in Rat Keratinocytes to Counter LiCl-Induced Inhibition of Proliferation and Migration

Figure 2

Cell proliferation of keratinocytes in response to LiCl and AS-IV treatment. (a) LiCl inhibits proliferation of mouse keratinocytes, as evidenced by the MTS/PMS assay. Data are expressed as a percentage of the control (100%) and represent the mean ± SD of three experiments. *𝑃<0.05, **𝑃<0.01. (b) LiCl induced a senescent-like morphology in live keratinocytes, as evidenced by phase-contrast microscopy. (c) Growth curve of keratinocytes in response to LiCl and AS-IV treatments. (d) OD at 490 nm of keratinocytes treated with or without LiCl and AS-IV for 72 h. Scale bar = 100 μm.

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