Endothelium/Nitric Oxide Mediates the Vasorelaxant and Antihypertensive Effects of the Aqueous Extract from the Stem Bark of Mammea africana Sabine (Guttiferae)
Table 1
Effects of chronic treatment (4 weeks) on the natriuresis, kaliuresis, glomerular filtration rate (GFR), and nitric oxide (NO) level in rat kidney.
Week 2
Week 3
Week 4
Na+
K+
Na+
K+
Na+
K+
GFR (mL/kg/min)
NO level (mol/g)
(mEq/kg/24 h)
(mEq/kg/24 h)
(mEq/kg/24 h)
(mEq/kg/24 h)
(mEq/kg/24 h)
(mEq/kg/24 h)
Control
L-NAME
L-NAME + Captopril
L-NAME + AEMA
GFR and NO level were measured at the end of the treatment (4 weeks). Data represent the mean ± SEM, . compared to control; compared to L-NAME.