Endothelium/Nitric Oxide Mediates the Vasorelaxant and Antihypertensive Effects of the Aqueous Extract from the Stem Bark of Mammea africana Sabine (Guttiferae)

Table 1

Effects of chronic treatment (4 weeks) on the natriuresis, kaliuresis, glomerular filtration rate (GFR), and nitric oxide (NO) level in rat kidney.

	Week 2		Week 3		Week 4
	Na^+	K^+	Na^+	K^+	Na^+	K^+	GFR; (mL/kg/min)	NO level; (𝜇mol/g)
	(mEq/kg/24 h)	(mEq/kg/24 h)	(mEq/kg/24 h)	(mEq/kg/24 h)	(mEq/kg/24 h)	(mEq/kg/24 h)
Control	13.60±1.08	14.50±1.03	11.09±0.66	10.86±1.33	12.02±1.22	10.22±1.82	0.10±0.02	1.71±0.19
L-NAME	9.08±1.47	9.94±0.95^a	11.48±0.76	13.12±0.74	11.55±1.61	12.10±1.62	0.12±0.02	0.96±0.14^a
L-NAME + Captopril	9.78±0.77	9.17±1.12^a	11.74±0.93	13.59±1.25	12.84±0.44	14.75±1.22	0.08±0.02	1.45±0.15
L-NAME + AEMA	11.92±0.36	10.48±0.88^a	12.22±1.18	12.81±1.38	10.61±0.42	11.08±1.06	0.14±0.02	1.70±0.13^𝛼

GFR and NO level were measured at the end of the treatment (4 weeks). Data represent the mean ± SEM, 𝑛=5. ^a𝑃<0.05 compared to control; ^𝛼𝑃<0.05 compared to L-NAME.