Evaluation of Chinese-Herbal-Medicine-Induced Herb-Drug Interactions: Focusing on Organic Anion Transporter 1

Figure 2

Concentration-dependent effects of (a) GZ, (b) LW, (c) CW, (d) CC, (e) CP, (f) HC, (g) LT, (h) HQ, and (i) HL on the uptake of [³H]-PAH in MDCK/hOAT1 cells. The cells were incubated with 2 μM [³H]-PAH in the presence of CHM extracts at 0.5, 1, 5, 10, 25, 50, 250, and 500 μg/mL for 1 min at at 37°C. The results were expressed as mean ± SE (𝑛=3).

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