Evaluation of Chinese-Herbal-Medicine-Induced Herb-Drug Interactions: Focusing on Organic Anion Transporter 1

Table 2

Effect of 33 CHM single herbs on [³H]-PAH uptake in MDCK II/hOAT1.

Inhibition order	Chinese herbal medicine	[^3H]-PAH uptake^a (% of control)	Significance^b
1	Huang Qin	50.76 ± 0.42	***
2	Huang Lien	62.71 ± 2.93	***
3	Chen Pi	73.43 ± 3.08	***
4	Bai Shouh	74.59 ± 1.22	***
5	Hwang Bs	75.46 ± 3.60	***
6	Huang Qi	77.50 ± 1.07	***
7	Ge Gen	77.52 ± 1.87	***
8	Suan Zao Ren	79.21 ± 2.05	***
9	Sha Ren	79.28 ± 5.33	***
10	Du Zhong	79.90 ± 9.46	***
11	Shiang Fu Zhi	82.50 ± 2.24	**
12	Ren San	83.73 ± 5.30	**
13	Sheng Di Huang	84.60 ± 6.44	*
14	Fu Ling	85.77 ± 1.49	*
15	Tan San	86.17 ± 6.47	*
16	Yi Yi Ren	87.33 ± 1.06	*
17	Chuan Kung	90.13 ± 6.57
18	Jin Yin Hua	90.41 ± 3.10
19	Ban Shia	90.60 ± 2.01
20	Tian Lou Gen	91.09 ± 5.99
21	San Yao	91.64 ± 1.99
22	Mai Men Tung	91.89 ± 7.06
23	Zhi Ke	92.93 ± 0.75
24	Yan Hu Nan	94.23 ± 2.69
25	Niu Shi	98.55 ± 4.03
26	Tang Kuei	98.13 ± 3.17
27	Bai Zhu	100.48 ± 4.89
28	Bai Zhi	101.99 ± 2.69
29	Shing Ren	104.68 ± 3.94
30	Chai Hu	105.87 ± 5.45
31	Fang Feng	107.05 ± 4.65
32	Jie Geng	111.14 ± 5.33	*
33	Gan Cao	115.99 ± 1.42	**

^aResults were expressed as mean ± SE (n = 3).
^bStatistics: one-way ANOVA, LSD post-hoc; significantly different from control.
(*P < 0.05, **P < 0.05, ***P < 0.001).