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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 967968, 9 pages
Research Article

Efficacy of Chuanxiong Ding Tong Herbal Formula Granule in the Treatment and Prophylactic of Migraine Patients: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial

1Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyun Cang, Dong Cheng District, Beijing 100700, China
2Key Laboratory for Internal Chinese Medicine of Ministry of Education and Beijing, Beijing University of Traditional Chinese Medicine, No. 5 Haiyun Cang, Dong Cheng District, Beijing 100700, China
3Department of Neurology, The Affiliated Hospital to Changchun University of Chinese Medicine, No. 1478 Gongnong Avenue, Chaoyang District, Changchun 130021, China
4Department of Traditional Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Dong Cheng District, Beijing 100050, China
5Department of Neurology, Taian Hospital of Traditional Chinese Medicine, No. 216 Yingxuan Avenue, Taian 271000, China
6Department of Neurology, Xiamen Hospital of Traditional Chinese Medicine, No. 1739 Xianyue Road, Xiamen 361001, China
7Department of Neurology, Hubei Hospital of Traditional Chinese Medicine, No. 4 Huayuan Shan,Wuchang District, Wuhan 430061, China
8Department of Neurology, The First Subsidiary Affiliated Hospital of Anhui College of Traditional Chinese Medicine, No.117 Meishan Road, Hefei 230031, China
9Department of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, No. 1 Xiyuan Playground, Haidian District, Beijing 100091, China
10China Academy of Chinese Medical Sciences, No. 16 South Street, Dong zhimen nei, Dong Cheng District, Beijing 100700, China

Received 25 July 2012; Accepted 24 September 2012

Academic Editor: Alan Bensoussan

Copyright © 2012 Caihong Fu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To evaluate the efficacy of traditional Chinese herbal ChuanXiong Ding Tong herbal formula granule (CXDT-HFG) for migraine patients with “the Syndrome of Liver Wind and Blood Stasis.” Methods. 150 migraine patients were recruited and assigned randomly in a double-blind, placebo-controlled study to receive CXDT-HFG ( ) plus necessary analgesics, or placebo ( ) plus necessary analgesics for 16 weeks (12 weeks’ intervention and 4 weeks’ follow up). Outcome measures included migraine days, frequency of migraine attacks, analgesics consumption for acute treatment, and the proportion of responders as well as the visual analogue scale (VAS) scores and intensity for pain. Results. Compared with the placebo group, the CXDT-HFG group showed significant reduction in migraine days and attacks frequency at week 12 and follow-up period ( ) as well as in the reduction of VAS scores at follow-up period.There was significant difference in the proportion of responders between the two groups at follow-up period ( ). However there were no significant differences between the two groups in analgesics consumption ( ). Conclusion. CXDT-HFG was more effective than placebo in decreasing days of migraine attacks, frequency, VAS scores, and relieving pain intensity for migraine patients.