Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Fig 2

Research Article

Hepatoprotective Effects of Total Triterpenoids and Total Flavonoids from Vitis vinifera L against Immunological Liver Injury in Mice

Figure 2

Histological image of liver tissues from ILI mice indicating the hepatoprotective effects of VTT and VTF. (a) Liver histopathologic examination showed no histological abnormalities in normal mice. (b) The liver tissue of ILI model mice, showing wide-range laminated necrosis, acidophilia changes, and portal infiltration. Significant hepatoprotective effects are seen in tissues primed with BCG and treated with (c) DDB (200 mg/kg), VTT at (d) 50, (e) 150, or (f) 300 mg/kg, or VTF at (g) 50, (H) 150, or (i) 300 mg/kg followed by LPS challenge. The degree of tissue damage was significantly reduced. The tissues were surgically excised and subjected to histological study by staining with hematoxylin and eosin. All the magnifications are ×100.

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