Lipid-Regulating Effect of Traditional Chinese Medicine: Mechanisms of Actions

Figure 1

The regulation of some vital targets related to lipid metabolism by TCM. TCM might regulate all processes of lipid metabolism such as the synthesis, absorption, transport and metabolism of cholesterol and TG. Targets related to the regulation of lipid metabolism by TCM herbs are mainly including HMGCR FAS, LDL-R, CEPT, LPL, HL, CYP7A1, PPPA-α, SREBP, and LXRa. Some Chinese herb active components including berberine, danshensu, curcumin and hawthorn flavonoids, and ginseng saponins may regulate the different processes of lipid metabolism, and some vital targets relate to lipid metabolism as the figure arrow showed. Red arrows present positive or upregulation. Green arrows demonstrate negative or downregulation.