Review Article
Lipid-Regulating Effect of Traditional Chinese Medicine: Mechanisms of Actions
Table 2
The regulation of transcription factors related to lipid metabolism by TCM.
| Herb/ingredients | PPAR-α/γ/δ | LXR-α | SREBPs | FXR | Others | Reference |
| Berberine | α(+), (+) | | SRE1 | | Insig-i(+), CPTIA | [23, 36–38, 50] | Curcumin | (+) | | | | | [25, 26] | Danshen/dihydrotanshinone 1, salvianolic acid, and Danshensu rosmarinic acid | α(+) | (+) | −1c(−) | (+) | ABCA1, ABCB4/11, SHP(+) | [40, 41] | Ginseng | α(+) | | | | | [45] | Gynostemma pentaphyllum/gypenoside | α(+) | | | | | [43] | Resin of the guggul tree/guggulsterone | | | | (−) | AR/GR/MR(−); PR/ERα(+) | [44] | Ligustrum lucidum/oleanolic acid | α(+), (+) | | | | protein kinase B (+) | [51] | Hawthorn, hawthorn-flavone | α(+) | | | | | [11, 24] | Morroniside | α(+) | | −1(−); −2(−) | | NF-kβ, iNOS, (−) | [52] | FTZ | α(+) | | (−) | | | [49] | Fenugreek (TEFS) | (−) | | −1(−) | | cEBP-α(−) | [42] |
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Notes for tables: (+): positive/upregulation; (−) negative/downregulation.
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