Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 3

Research Article

Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack)

Table 3

Micronucleus assay of E. longifolia powdered root in vivo.

TreatmentDose Frequency of micronucleated polychromatic erythrocyte (‰) Ratio of polychromatic erythrocyte (PCE) to total erythrocytes (%)
Day 1Day 2Day 3Day 1Day 2Day 3

Negative10
Positive cyclophosphamide (mg/kg b.w.)200
E. longifolia powdered root (g/kg b.w.)0.6
1.2
2.0

Both the ratios of polychromatic erythrocyte (PCE) to total erythrocytes (%) and the frequency of micronucleated polychromatic erythrocyte (%) in treated group were not statistically different from those of the negative control animals, suggesting that the treatment with E. longifolia powdered root did not cause erythropoietic cell toxicity and genotoxicity in vivo. Data were expressed as Mean ± S.D. . Statistical analysis: , and indicate a statistical difference with the control group by one-way ANOVA.
Mice in negative control group received single gavage of vehicle (sterile water).

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