|
| Reference | Study model | Constituents | Laboratory findings |
|
| [12] | Renovascular hypertensive rat | NS oil (i.p.)
0.2 mL/kg | ↓ SBP, tissue MDA, luminol, and lucigenin CL
↑ tissue Na+ and K+-ATPase
↓ plasma CK, LDH, and ADMA
↑ plasma NO |
|
| [15] | Rat | (a) NS oil (i.v.)
4–32 μL/kg
(b) TQ (i.v.)
0.2–1.6 mg/kg | ↓ arterial BP and heart rate
(dose dependent) |
|
| [16] | Guinea pig | NS oil (i.v.)
4–32 μL/kg | ↓ arterial BP and heart rate
(dose dependent) |
|
| [17] | Rat | (a) De-TQ volatile oil (i.v.)
2–16 μL/kg
(b) α-pinene (i.v.)
1–4 μL/kg
(c) p-cymene (i.v.)
2–16 μL/kg | ↓ arterial BP and heart rate
(dose dependent)
*De-TQ volatile oil and p-cymene:
4, 8, and 16 μL/kg
*α-pinene:
2 and 4 μL/kg |
|
| [18] | Rat | Thymol
(in vitro) | ↓ aortic contraction
(dose dependent) |
|
| [19] | Canine and guinea pig | Thymol
(in vitro) | Negative inotropic action
(dose dependent) |
|
| [20] | Spontaneously hypertensive rat | NS seed extract (p.o.)
0.6 mL/kg | ↑ diuresis
↓ arterial BP |
|
| [21] | Spontaneously hypertensive rat | NS extract (p.o.)
| ↓ SBP
↑ GFR, urinary and electrolyte output |
|
| [22] | L-NAME-induced
hypertensive rat | TQ (p.o.)
0.5 mg/kg and
1 mg/kg | ↓ SBP and serum creatinine
↑ kidney GSH |
|
| [23] | L-NAME-induced hypertensive rat | NS seed extract (p.o.)
400 mg/kg | ↓ arterial BP, SBP, DBP, and serum LDH
↑ serum NO |
|
| [24] | Patients with mild hypertension | NS seed extract (p.o.)
100 mg/kg and
200 mg/kg | ↓ SBP and DBP
(dose dependent)
↓ total and LDL cholesterol |
|
