Effect of the Copaifera langsdorffii Desf. Leaf Extract on the Ethylene Glycol-Induced Nephrolithiasis in Rats
Immunohistochemical analyses of renal tubules stained for OPN. Copaiba leaf extract group: no OPN synthesis was detected (a). EG 1% group: increased OPN synthesis in the renal tubules epithelium was observed (b). Prophylactic group: OPN expression decreased in relation to the EG 1% group (c). Post-stone treatment group: increased OPN synthesis in renal tubules is similar to that in EG 1% group (d). (40x of magnification).