Electroacupuncture Reduces Cocaine-Induced Seizures and Mortality in Mice

Figure 2

Effects of EA at different frequencies (2 Hz, 50 Hz, and 100 Hz), needle insertion exerted at GV14 and GV20 acupoints, and sham EA (50 Hz; at bilateral SI11) on cocaine-induced seizures. Mice were administered with cocaine (75 mg/kg; i.p.) at 1 min after EA or needle insertion. Seizure severity was measured by the Itzhak five-stage scale [18]. Between-group comparisons for each group were performed by one-way ANOVA followed by Tukey’s test (*𝑃<0.05; **𝑃<0.01; n: the number of animals).