Electroacupuncture Reduces Cocaine-Induced Seizures and Mortality in Mice
Figure 6
(a) Representative photomicrographs of c-Fos expression induced by cocaine in the paraventricular thalamus and the effects of EA. c-Fos expression was not observed among saline controls, whereas c-Fos expression was evident in the paraventricular thalamus among animals in the EA-alone, cocaine-alone (75 mg/kg; i.p.), and cocaine plus EA groups. (b) Effects of EA on controls and cocaine-induced c-Fos expression in the paraventricular thalamus. The numbers of c-Fos positive nuclei were counted and averaged from three randomly chosen sections from each animal in each group. EA at 50 Hz was applied to the GV14 and GV20 acupoints. EA increased c-Fos expression in the paraventricular thalamus, while EA decreased the number of c-Fos positive nuclei induced by cocaine. Between-group comparisons for each group were performed by ANOVA, followed by Tukey’s test (*; ***; n: the number of animals).
