Electroacupuncture Reduces Cocaine-Induced Seizures and Mortality in Mice
Figure 7
(a) Representative photomicrographs of c-Fos expression induced by cocaine in the amygdala and the effects of EA. Whereas c-Fos expression was absent among animals in the saline control and EA plus saline groups, c-Fos expression in the amygdala was observed in animals treated with cocaine (75 mg/kg; i.p.) and cocaine plus EA. (b) Effects of EA on controls and cocaine-induced c-Fos expression in the amygdala. The numbers of c-Fos positive nuclei were counted and averaged from three randomly chosen sections from each animal in each group. EA at 50 Hz was applied to the GV14 and GV20 acupoints. Cocaine administration induced a marked level of c-Fos expression, while EA did not significantly decrease the number of c-Fos positive nuclei induced by cocaine. Between-group comparisons for each group were performed by ANOVA, followed by Tukey’s test (***; n: the number of animals).
