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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 134852, 9 pages
Research Article

Catalpol Induces Neuroprotection and Prevents Memory Dysfunction through the Cholinergic System and BDNF

1Department of Emergency, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
2Chongqing Chemical Industry Vocational College, 400020, China
3College of Pharmaceutical Sciences and Traditional Chinese Medicine, Southwest University, Chongqing 400715, China
4Chongqing Engineering Research Center for Pharmacological Evaluation, Chongqing 400715, China
5Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

Received 7 January 2013; Revised 19 June 2013; Accepted 25 July 2013

Academic Editor: Wei Jia

Copyright © 2013 Dong Wan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To investigate the role and mechanism of catalpol on neuroprotective effects and memory enhancing effects simultaneously, neuroprotective effects of catalpol were assessed by neurological deficits score, TTC staining, and cerebral blood flow detecting. Morris water maze was employed to investigate its effects on learning and memory and then clarify its possible mechanisms relating the central cholinergic system and BDNF. Edaravone and oxiracetam were used for positive control drugs based on its different action. Results showed that catalpol and edaravone significantly facilitated neurological function recovery, reduced infarction volume, and increased cerebral blood flow in stroke mice. Catalpol and oxiracetam decreased the escape latency significantly and increased the numbers of crossing platform obviously. The levels of ACh, ChAT, and BDNF in catalpol group were increased in a dose-dependent manner, and AChE declined with a U-shaped dose-response curve. Moreover, the levels of muscarinic AChR subtypes M1 and M2 in hippocampus were considerably raised by catalpol. These results demonstrated that catalpol may be useful for neuroprotection and memory enhancement, and the mechanism may be related to the central cholinergic system.