Sulforaphane Attenuates Gentamicin-Induced Nephrotoxicity: Role of Mitochondrial Protection

Figure 8

SFN attenuates GM-induced apoptosis.(a–d) Immunohistochemical detection of apoptosis by TUNEL. Sections of renal cortex of (c) rats treated with GM show nuclei intensely stained which indicate tubular cells in apoptosis. (c) There are also several nuclei of glomerular TUNEL-positive cells. Apoptosis was significantly attenuated in (d) the SFN + GM group. Basal staining was observed in renal sections from (a) CT and (b) SFN groups (40x). (e) Quantitative analysis confirms a remarkable protection of SFN against GM-induced apoptotic death in the SFN + GM group. Data are mean±SEM. ^∗𝑃<0.001 versus CT and SFN; ^#𝑃<0.001 versus GM.

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