Figure 8: SFN attenuates GM-induced apoptosis.(a–d) Immunohistochemical detection of apoptosis by TUNEL. Sections of renal cortex of (c) rats treated with GM show nuclei intensely stained which indicate tubular cells in apoptosis. (c) There are also several nuclei of glomerular TUNEL-positive cells. Apoptosis was significantly attenuated in (d) the SFN + GM group. Basal staining was observed in renal sections from (a) CT and (b) SFN groups (40x). (e) Quantitative analysis confirms a remarkable protection of SFN against GM-induced apoptotic death in the SFN + GM group. Data are . versus CT and SFN; versus GM.