Evidence-Based Complementary and Alternative Medicine

Review Article

A Systematic Review and Meta-Analysis of Buyang Huanwu Decoction in Animal Model of Focal Cerebral Ischemia

Table 1

Design characteristics of included studies.
StudySpeciesStroke modelMethod of administrationOutcome measure (treated/control)Quality score
Bai and Cai [20]
2007		Male, SD ratsPermanent MCAO14 d after occlusion;
i.g.; 11.14 g/Kg, daily		Neurobehavioral score
Bai et al. [21]
2011		Male, SD ratsPermanent MCAO14 d after occlusion;
i.g.; 11.14 g/Kg, daily		Neurobehavioral score
Cai et al. [6]
2007		Male, Wistar ratsTemporary MCAO2 h after occlusion;
i.g.; 5 g/Kg, daily		Combined
Cao and Jiang [22]
2004		Male, SD rats Temporary MCAO 3 d before occlusion;
i.p.; 4 g/Kg, daily		Neurobehavioral score
Chen et al. [23]
2011		Male, SD rats Temporary MCAO7 d before occlusion;
i.g.; 40 g/Kg, daily		Neurobehavioral score
Chu et al. [24]
2005		Male, SD rats Temporary MCAO7 d before occlusion;
i.g.; 13.3 g/Kg, daily		Neurobehavioral score
Chu et al. [25]
2006		Male, SD rats Temporary MCAO7 d before occlusion;
i.g.; 13.3 g/Kg, daily		Combined
Chu et al. [26]
2006		Male, SD rats Temporary MCAO7 d before occlusion;
i.g.; 26 g/Kg, daily
13 g/Kg, daily		Neurobehavioral score
Chu et al. [27]
2011		Male, SD ratsTemporary MCAO24 h after occlusion;
i.g.; 13 g/Kg, daily		Neurobehavioral score
Chu et al. [8]
2011		Male, KM mice Temporary MCAO24 h after occlusion;
i.g.; 20 g/Kg, daily		Neurobehavioral score
Du and Wang [28]
2008		Male, SD rats ? MCAOImmediately after occlusion;
i.g.; 26.6 g/Kg, daily		Neurobehavioral score
Du et al. [29]
2011		Male, SD ratsTemporary MCAO2 h after occlusion;
i.g.; 14.2 g/Kg, daily		Neurobehavioral score
Gao and Cai [30]
2004		Male, SD ratsTemporary MCAOImmediately after occlusion;
i.p.; 16 g/Kg, daily		Combined
Gao et al. [31]
2008		Male, SD ratsTemporary MCAO5 d before occlusion;
i.g.; 13.3 g/Kg, daily		Neurobehavioral score
Gao et al. [32]
2009		Male, SD ratsTemporary MCAO5 d before occlusion;
i.g.; 13 g/Kg, daily		Neurobehavioral score
(6/6)
Gao et al. [9]
2009		Male, SD ratsTemporary MCAO5 d before occlusion;
i.g.; 26 g/Kg, daily,
13 g/Kg, daily, and
6.5 g/Kg, daily		Neurobehavioral score
Guo et al. [33]
2004 		Male, SD ratsTemporary MCAO1 h after occlusion;
i.p.; 10 g/Kg, daily		Combined
Han et al. [34]
2001		Male, Wistar rats Photothrombotic
MCAO		7 d before occlusion;
i.g., 12.8 g/Kg, daily		Infarction size
Jiang and Zhang [35]
2004		Male, SD ratsTemporary MCAO2 h after occlusion;
i.p.; 4.9 g/Kg, daily		Infarction size
Jiang et al. [36]
2005		Male, SD ratsTemporary MCAOImmediately after occlusion;
i.p.; 5.8 g/Kg, daily		Neurobehavioral score
Jiang et al. [14]
2005		Male, SD rats ? MCAO5 d before occlusion;
i.p.; 29 g/Kg, daily		Neurobehavioral score
Li and Cai [13]
2007		Male, SD rats Temporary MCAO2 h after occlusion;
i.g.; 14 g/Kg, daily		Combined
Li and Wang [37]
2011		Male, SD ratsTemporary MCAO4 d after occlusion;
i.g.; 6.4 g/Kg, daily		Neurobehavioral score
Liang and Zhang [38]
2010		Male, SD rats ? MCAO24 h after occlusion;
i.g.; 7.15 g/Kg, daily		Combined
Liao and Tong [15]
2004		Male, SD ratsTemporary MCAO7 d before occlusion;
i.g.; 12.96 g/Kg, daily		Combined
Liu and Wu [39]
2004		Male, SD ratsTemporary MCAO7 d before occlusion;
i.g.; 20 g/Kg, daily and
10 g/Kg, daily		Combined
Liu et al. [40]
2005		Male, SD ratsTemporary MCAO7 d before occlusion;
i.g., 20 g/Kg, daily and
10 g/Kg, daily		Infarction size
Liu and Peng [41]
2005		Male, Wistar rats Permanent MCA cauterization20 d after occlusion;
i.g.; 14 g/Kg, daily		Neurobehavioral score
Liu et al. [42]
2007		Male, Wistar rats Permanent MCAO2 h after occlusion;
i.g.; 14.2 g/Kg, daily		Neurobehavioral score
Liu et al. [43]
2008		Mixed, Wistar ratsPermanent MCAO2 h after occlusion;
i.g.; 13.8 g/Kg, daily		Neurobehavioral score
Liu et al. [44]
2012		Mixed, SD rats Permanent MCAO4 d before occlusion;
i.g.; 13 g/Kg, daily		Combined
Lu and Peng [45]
2008		Male, Wistar rats Permanent MCA cauterization15 d after occlusion;
i.g.; 50 g/Kg, daily,
25 g/Kg, daily, and
12.5 g/Kg, daily		Neurobehavioral score
Ma and Fang [46]
2009		Male, SD rats Temporary MCAO7 d before occlusion;
i.g.; 60 g/Kg, daily		Combined
Mo and Zheng [47]
1997		Mixed, S rats Permanent MCA cauterization7 d before occlusion;
i.g.; 13.8 g/Kg, daily		Infarction size
Su et al. [48]
2012		Male, SD rats Temporary MCAO24 h after occlusion;
i.g.; 12 g/Kg, daily		Combined
Sun and Peng [49]
2004		Male, Wistar rats Permanent MCA cauterization20 d after occlusion;
i.g.; 50 g/Kg, daily,
25 g/Kg, daily, and
12.5 g/Kg, daily		Neurobehavioral score
Sun et al. [50]
2010		Male, SD rats Temporary MCAO7 d before occlusion;
i.g.; 25.7 g/Kg, daily		Neurobehavioral score
Tan et al. [51]
2006		Male, Wistar rats Permanent MCA cauterization20 d after occlusion;
i.g.; 25.66 g/Kg, daily and
6.42 g/Kg, daily		Neurobehavioral score
Tian and Liu [52]
2010		Male, SD rats ? MCAO2 h after occlusion;
i.g.; 6 g/Kg, daily		Combined
Wang et al. [53]
2005		Male, SD rats Temporary MCAO5 d before occlusion;
i.g.; 20 g/Kg, daily and
10 g/Kg, daily		Combined
Wang et al. [54]
2006		Male, SD rats Temporary MCAO7 d before occlusion;
i.g.; 24 g/Kg, daily		Combined
Wang et al. [55]
2010		Male, Wistar rats Embolic MCAO24 h after occlusion;
i.g.; 10 g/Kg, daily		Neurobehavioral score
Wang et al. [5]
2011		Male, ICR mice Temporary MCAO2 h after occlusion;
i.g.; 2 g/Kg, daily and
1 g/Kg, daily		Infarction size
Wei et al. [56]
2010		Male, Wistar rats Temporary MCAO3 d before occlusion;
i.g.; 10 g/Kg, daily		Combined
Wu and Luo [57]
2008		Male, SD rats Temporary MCAO1 h after occlusion;
i.g.; 13.3 g/Kg, daily		Combined
Xu and Liao [58]
2006		Male, Wistar rats Temporary MCAOImmediately after occlusion;
i.p.; 10 g/Kg, daily		Combined
Xue [59]
2006		Male, SD rats Temporary MCAO3 d before occlusion;
i.g.; 8.4 g/Kg, daily and
4.2 g/Kg, daily		Infarction size
Yang [60]
2010		Male, SD rats Temporary MCAO7 d before occlusion;
i.g.; 13 g/Kg, daily,
4.3 g/Kg, daily, and
1.45 g/Kg, daily		Combined
Yi et al. [61]
2010		Male, Wistar rats ? MCAO2 h after occlusion;
i.g.; 14.2 g/Kg, daily		Combined
Yin and Cai [16]
2007		Male, SD rats Permanent MCAO2 h after occlusion;
i.p.; 5.9 g/Kg, daily		Neurobehavioral score
Yin and Wu [62]
2012		Male, gerbils Temporary MCAO7 d before occlusion;
i.g.; 51 g/Kg, daily		Infarction size
Zhang et al. [63]
2009		Male, Wistar rats ? MCAO7 d before occlusion;
i.g.; 25 g/Kg, daily		Combined
Zhao et al. [64]
2005		Male, SD rats Temporary MCAO0.5 h after occlusion;
i.g.; 1.4 g/Kg, daily		Combined
Zhao and Qu [65]
2007		Male, SD rats Temporary MCAO7 d before occlusion;
i.g.; 12.8 g/Kg, daily		Infarction size
Zhao et al. [11]
2012		Mixed, Wistar rats Temporary MCAO0.5 h, 1 h, 2 h, 4 h, and 6 h after occlusion;
i.g.; 40 g/Kg, daily		Infarction size
Zhou and Cai [66]
2012		Male, SD rats Permanent MCAO2 h after occlusion;
i.g.; 5 g/Kg, daily		Combined
Note: (a) stroke model: temporary or permanent MCAO (suture-occluded method), permanent MCA cauterization; photothrombotic MCA; embolic MCA.
(b) Method of administration: time of administration; route of drug delivery; dose range given in the first 24 h.
i.g.: intragastric administration; i.p.: intraperitoneal injection. MCAO: middle cerebral artery occlusion; MCA: middle cerebral artery.