Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 145925, 7 pages
http://dx.doi.org/10.1155/2013/145925
Research Article

Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity

1R&D Centre, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Industrial Area, 19th K.M. Stone, Hosur Road, Bangalore, Karnataka 560100, India
2Center for Bioseparation Technology, VIT University, Vellore, Tamil Nadu 632014, India

Received 22 July 2013; Revised 30 September 2013; Accepted 2 October 2013

Academic Editor: C. S. Cho

Copyright © 2013 Chandrasekaran Chinampudur Velusami et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. V. Chandrasekaran, M. A. Vijayalakshmi, K. Prakash, V. S. Bansal, J. Meenakshi, and A. Amit, “Review: herbal approach for obesity management,” American Journal of Plant Sciences, vol. 3, pp. 1003–1014, 2012. View at Google Scholar
  2. W. La-Ongsri, C. Trisonthi, and H. Balslev, “Management and use of Nelumbo nucifera Gaertn. in Thai wetlands,” Wetlands Ecology and Management, vol. 17, no. 4, pp. 279–289, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Kulkarni and A. Juvekar, “Attenuation of acute and chronic restraint stress-induced perturbations in experimental animals by Nelumbo nucifera Gaertn,” Indian Journal of Pharmaceutical Sciences, vol. 70, no. 3, pp. 327–332, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Ono, E. Hattori, Y. Fukaya, S. Imai, and Y. Ohizumi, “Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats,” Journal of Ethnopharmacology, vol. 106, no. 2, pp. 238–244, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Rai, A. Wahile, K. Mukherjee, B. P. Saha, and P. K. Mukherjee, “Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds,” Journal of Ethnopharmacology, vol. 104, no. 3, pp. 322–327, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. D.-H. Sohn, Y.-C. Kim, S.-H. Oh, E.-J. Park, X. Li, and B. Lee, “Hepatoprotective and free radical scavenging effects of Nelumbo nucifera,” Phytomedicine, vol. 10, no. 2-3, pp. 165–169, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. P. K. Mukherjee, K. Saha, J. Das, M. Pal, and B. P. Saha, “Effect of Nelumbo nucifera rhizome extract on blood sugar level in rats,” Journal of Ethnopharmacology, vol. 58, no. 3, pp. 207–213, 1997. View at Publisher · View at Google Scholar · View at Scopus
  8. P. K. Mukherjee, K. Saha, J. Das, M. Pal, and B. P. Saha, “Studies on the anti-inflammatory activity of rhizomes of Nelumbo nucifera,” Planta Medica, vol. 63, no. 4, pp. 367–369, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. P. V. Chakravarthi and N. Gopakumar, “Anti-inflammatory activity of red and white lotus seeds (Nelumbo nucifera) in albino rats,” Veterinary World, vol. 3, no. 4, pp. 157–159, 2010. View at Google Scholar
  10. P. K. Mukherjee, J. Das, K. Saha, S. N. Giri, M. Pal, and B. P. Saha, “Antipyretic activity of Nelumbo nucifera rhizome extract,” Indian Journal of Experimental Biology, vol. 34, no. 3, pp. 275–276, 1996. View at Google Scholar · View at Scopus
  11. M. Li and Z. Xu, “Quercetin in a lotus leaves extract may be responsible for antibacterial activity,” Archives of Pharmacal Research, vol. 31, no. 5, pp. 640–644, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Mukherjee, A. Biswas, S. Bhadra et al., “Exploring the potential of Nelumbo nucifera rhizome on membrane stabilization, mast cell protection, nitric oxide synthesis, and expression of costimulatory molecules,” Immunopharmacology and Immunotoxicology, vol. 32, no. 3, pp. 466–472, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Mukherjee, T. N. Khatua, P. Venkatesh, B. P. Saha, and P. K. Mukherjee, “Immunomodulatory potential of rhizome and seed extracts of Nelumbo nucifera Gaertn,” Journal of Ethnopharmacology, vol. 128, no. 2, pp. 490–494, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. P. K. Mukherjee, D. Mukherjee, A. K. Maji, S. Rai, and M. Heinrich, “The sacred lotus (Nelumbo nucifera): phytochemical and therapeutic profile,” Journal of Pharmacy and Pharmacology, vol. 61, no. 4, pp. 407–422, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. R. P. Rastogi and B. N. Mehrotra, Compendium of Indian Medicinal Plants, vol. 1 of (1960–1969), pp. 288-289, Central Drug Research Institute, Lucknow and Publications & Information Directorate, New Delhi, India, 1991.
  16. Y. Huang, L. Zhao, Y. Bai, P. Liu, J. Wang, and J. Xiang, “Simultaneous determination of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn. in rat plasma by a rapid HPLC method and its application to a pharmacokinetic study,” Arzneimittel-Forschung, vol. 61, no. 6, pp. 347–352, 2011. View at Google Scholar · View at Scopus
  17. B. Xie, J. Wan, W. Wang, C. Shi, X. Hou, and J. Fang, “Nelumbo nucifera alkaloid inhibits 3T3-L1 preadipocyte differentiation and improves high-fat diet-induced obesity and body fat accumulation in rats,” Journal of Medicinal Plant Research, vol. 5, no. 10, pp. 2021–2028, 2011. View at Google Scholar · View at Scopus
  18. X. Shuangshuang, D. Wenjuan, F. Lei, S. Yu, D. Hongjing, and W. Xiao, “Isolation and characterization of chemical constituents from the petals of Nelumbo nucifera,” Asian Journal of Chemistry, vol. 24, pp. 4619–4622, 2012. View at Google Scholar
  19. C. Wu, M. Yang, K. Chan, P. Chung, T. Ou, and C. Wang, “Improvement in high-fat diet-induced obesity and body fat accumulation by a Nelumbo nucifera leaf flavonoid-rich extract in mice,” Journal of Agricultural and Food Chemistry, vol. 58, no. 11, pp. 7075–7081, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. J. H. Ahn, E. S. Kim, C. Lee et al., “Chemical constituents from Nelumbo nucifera leaves and their anti-obesity effects,” Bioorganic and Medicinal Chemistry Letters, vol. 23, no. 12, pp. 3604–3608, 2013. View at Google Scholar
  21. S. Qi and D. Zhou, “Lotus seed epicarp extract as potential antioxidant and anti-obesity additive in Chinese Cantonese Sausage,” Meat Science, vol. 93, no. 2, pp. 257–262, 2013. View at Google Scholar
  22. J. S. You, Y. J. Lee, K. S. Kim, S. H. Kim, and K. J. Chang, “Antiobesity and hypolipidemic effects of Nelumbo nucifera seed ethanol extract in human preadipocytes and rats fed a high-fat diet,” Journal of the Science of Food and Agriculture. View at Publisher · View at Google Scholar
  23. G. Xingfeng, W. Daijie, D. Wenjuan, D. Jinhua, and W. Xiao, “Preparative isolation and purification of four flavonoids from the petals of Nelumbo nucifera by high-speed counter-current chromatography,” Phytochemical Analysis, vol. 21, no. 3, pp. 268–272, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,” Journal of Immunological Methods, vol. 65, no. 1-2, pp. 55–63, 1983. View at Google Scholar · View at Scopus
  25. US patent publication number: US, 2008/0317821 A1, dated December 2008.
  26. R. B. Birari and K. K. Bhutani, “Pancreatic lipase inhibitors from natural sources: unexplored potential,” Drug Discovery Today, vol. 12, no. 19-20, pp. 879–889, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Liu, D. Li, B. Huang, Y. Chen, X. Lu, and Y. Wang, “Inhibition of pancreatic lipase, α-glucosidase, α-amylase, and hypolipidemic effects of the total flavonoids from Nelumbo nucifera leaves,” Journal of Ethnopharmacology, vol. 149, pp. 263–269, 2013. View at Google Scholar
  28. R. Siegner, S. Heuser, U. Holtzmann et al., “Lotus leaf extract and L-carnitine influence different processes during the adipocyte life cycle,” Nutrition and Metabolism, vol. 7, article 66, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. E. Ohkoshi, H. Miyazaki, K. Shindo, H. Watanabe, A. Yoshida, and H. Yajima, “Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice,” Planta Medica, vol. 73, no. 12, pp. 1255–1259, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. U. J. Youn, J. Lee, Y. J. Lee, J. W. Nam, H. Bae, and E. Seo, “Regulation of the 5-HT3A receptor-mediated current by alkyl 4-hydroxybenzoates isolated from the seeds of Nelumbo nucifera,” Chemistry and Biodiversity, vol. 7, no. 9, pp. 2296–2302, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Oh, S. Y. Ryu, S. Lee et al., “Melanin-concentrating hormone-1 receptor antagonism and anti-obesity effects of ethanolic extract from Morus alba leaves in diet-induced obese mice,” Journal of Ethnopharmacology, vol. 122, no. 2, pp. 216–220, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Chen, Y. Xiang, J. Deng, Y. Liu, and S. Li, “Simultaneous analysis of anthocyanin and non-anthocyanin flavonoid in various tissues of different lotus (Nelumbo) cultivars by HPLC-DAD-ESI-MS(n),” Public Library of Science One, vol. 8, no. 4, Article ID e62291, 2013. View at Google Scholar
  33. S. Nakamura, S. Nakashima, G. Tanabe et al., “Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells,” Bioorganic Medicinal Chemistry, vol. 21, no. 3, pp. 779–787, 2013. View at Google Scholar
  34. M. Galleano, V. Calabro, P. D. Prince et al., “Flavonoids and metabolic syndrome,” Annals of the New York Academy of Sciences, vol. 1259, pp. 87–94, 2012. View at Google Scholar
  35. P. Kunanusorn, A. Panthong, P. Pittayanurak, S. Wanauppathamkul, N. Nathasaen, and V. Reutrakul, “Acute and subchronic oral toxicity studies of Nelumbo nucifera stamens extract in rats,” Journal of Ethnopharmacology, vol. 134, no. 3, pp. 789–795, 2011. View at Publisher · View at Google Scholar · View at Scopus