Involvement of Potassium Channels in Vasorelaxant Effect Induced by Valeriana prionophylla Standl. in Rat Mesenteric Artery

Table 1

Participation of K⁺ channels in the vasorelaxation induced by VPR in mesenteric artery rings precontracted with phenylephrine.

Condition experimental	Maximum response (MR) (% relaxation)	EC50 (95% confidence interval)	𝑛
Intact endothelium	75.43±4.1	5.97 (3.8–9.3)	6
Denuded endothelium	70.33±4.6^#	39.6 (27.2–57.6)*	5
KCl (80 mM)	40.00±8.2^##	92.9 (62.1–138.9)**	5
KCl (20 mM)	50.48±6.0^##	21.2 (11.4–39.2)^ns	5
TEA (3 mM)	46.79±6.1^##	53.9 (35.7–81.3)^ns	8
TEA (1 mM)	49.33±6.4^##	29.9 (16.0–56.0)^ns	7
4-AP (1 mM)	64.88±5.1^ns	24.8 (15.4–40.2)^ns	5
Glib (10 𝜇M)	64.32±3.5^ns	10.7 (6.6–17.3)^ns	5
BaCl2 (30 𝜇M)	63.14±6.1^ns	12.7 (7.2–22.3)^ns	5

Values are expressed as mean ± SEM; unpaired Student’s 𝑡-tests were used to examine the difference between denuded endothelium and intact endothelium; one-way ANOVAs with the addition of Bonferroni's multiple comparisons post hoc test were used to compare denuded endothelium (control) with different inhibitors groups. ^#No significance versus intact endothelium, *𝑃<0.05 versus intact endothelium; **𝑃<0.01 versus denuded endothelium; ^##𝑃<0.01 versus denuded endothelium; ^nsno significance versus denuded endothelium.