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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 149468, 10 pages
Review Article

Efficacy and Safety of Medicinal Plants or Related Natural Products for Fibromyalgia: A Systematic Review

1Department of Physiology, Federal University of Sergipe, Marechal Rondom Avenue, 49000-100 São Cristovão, SE, Brazil
2Collegiate of Physical Therapy, Federal University of Sergipe, Cláudio Batista Street, 49060-100 Aracaju, SE, Brazil
3Department of Nursing and Pharmacy, Federal University of Alagoas, Lourival de Mello Motta Avenue, 57072-970 Maceió, AL, Brazil
4Department of Pharmaceutical Sciences, Federal University of São Francisco Valley, José de Sá Maniçoba Avenue, 56304205 Petrolina, PE, Brazil
5Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Octávio Pinheiro Brisola Street, 17012-901 Bauru, SP, Brazil

Received 1 April 2013; Accepted 14 May 2013

Academic Editor: Cayetano Alegre

Copyright © 2013 Simone de Souza Nascimento et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To assess the effects of medicinal plants (MPs) or related natural products (RNPs) on fibromyalgia (FM) patients, we evaluate the possible benefits and advantages of MP or RNP for the treatment of FM based on eight randomized placebo-controlled trials (RCTs) involving 475 patients. The methodological quality of all studies included was determined according to JADAD and “Risk of Bias” with the criteria in the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0. Evidence suggests significant benefits of MP or RNP in sleep disruption, pain, depression, joint stiffness, anxiety, physical function, and quality of life. Our results demonstrated that MP or RNP had significant effects on improving the symptoms of FM compared to conventional drug or placebo; longer tests are required to determine the duration of the treatment and characterize the long-term safety of using MP, thus suggesting effective alternative therapies in the treatment of pain with minimized side effects.