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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 160357, 11 pages
Research Article

Modulation of Brain Electroencephalography Oscillations by Electroacupuncture in a Rat Model of Postincisional Pain

1Neuroscience Research Institute, Peking University, Beijing 100191, China
2State Key Lab of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
3Institute of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China
4Key Laboratory for Neuroscience, Ministry of Education/Ministry of Health, Beijing 100191, China

Received 21 January 2013; Revised 1 March 2013; Accepted 21 March 2013

Academic Editor: Lijun Bai

Copyright © 2013 Jing Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present study aimed to investigate how ongoing brain rhythmical oscillations changed during the postoperative pain and whether electroacupuncture (EA) regulated these brain oscillations when it relieved pain. We established a postincisional pain model of rats with plantar incision to mimic the clinical pathological pain state, tested the analgesic effects of EA, and recorded electroencephalography (EEG) activities before and after the EA application. By analysis of power spectrum and bicoherence of EEG, we found that in rats with postincisional pain, ongoing activities at the delta-frequency band decreased, while activities at theta-, alpha-, and beta-frequency bands increased. EA treatment on these postincisional pain rats decreased the power at high-frequency bands especially at the beta-frequency band and reversed the enhancement of the cross-frequency coupling strength between the beta band and low-frequency bands. After searching for the PubMed, our study is the first time to describe that brain oscillations are correlated with the processing of spontaneous pain information in postincisional pain model of rats, and EA could regulate these brain rhythmical frequency oscillations, including the power and cross-frequency couplings.