Cyclohexylmethyl Flavonoids Suppress Propagation of Breast Cancer Stem Cells via Downregulation of NANOG

<table>NANOG overexpression enhanced propagation of cancer stem cells. Control, NANOG-overexpressing and NANOG-knockdown MCF-7 cells were double-stained with anti-CD24 and anti-CD44 antibodies followed by FACS analysis (<svg height="11.125" id="M45" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.125" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>). CD44<sup>+</sup> cell population (top panel) and CD24<sup>−</sup>/low in CD44<sup>+</sup> cell population (bottom panel) were analyzed. </table>

Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: Cyclohexylmethyl Flavonoids Suppress Propagation of Breast Cancer Stem Cells via Downregulation of NANOG 