Cyclohexylmethyl Flavonoids Suppress Propagation of Breast Cancer Stem Cells via Downregulation of NANOG

Figure 5

P53-binding site existed in the regulatory region of NANOG and NANOGP8. The upper panel presents the detection of the p53-binding site in the 5-kb upstream sequence of the translation start site of a gene. The percentage of maximum possible score stands for the possibility of being a p53-binding site. The cutoff value was set as 80% to unveil the p53-binding site candidates. The most likely p53-binding site is indicated by asterisk. The lower panel exhibits the prediction of the promoter region. The triangle indicates the possible promoter region with the score of more than 0.7. *𝑃<0.05 or **𝑃<0.01.

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