Composition and Antidiarrheal Activity of Bidens odorata Cav.

Table 2

Antidiarrheal activity of CBO on mice with castor-oil-, MgSO₄-, arachidonic-acid-, and prostaglandin-E₂-induced diarrhea^a.

Cathartic agent	Treatment	Doses mg/kg	Percentage of inhibition
Magnesium sulphate	Vehicle	1 mL	0.0
	CBO	50	66.7±6.7^∗
		100	84.9±3^∗
		200	69.7±6.0^∗
	Loperamide	2.5	87.5±3.3
Castor oil	Vehicle	1 mL	0.0
	CBO	50	17.54±4.6
		100	45.6±6.3^∗
		200	72.7±5.3^∗
		300	77.1±1^∗
	Loperamide	2.5	89.77±5.4
Arachidonic acid	Vehicle	0.1 mL	0.0
	CBO	100	45.8±4.8^∗
		200	62.5±4.5^∗
	Loperamide	2.5	75.3±0.3
Prostaglandins E2	Vehicle	0.1 mL	0.0
	CBO	100	0.0
		200	0.0
	Loperamide	2.5	75.3±0.3

aThe results are the mean of 15 animals ± standard error.
bSignificant difference was found: ^∗𝑃<0.05.