Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 172548, 10 pages
http://dx.doi.org/10.1155/2013/172548
Research Article

Triptolide-Mediated Apoptosis by Suppression of Focal Adhesion Kinase through Extrinsic and Intrinsic Pathways in Human Melanoma Cells

1College of Natural Resources and Life Science, Dong-A University, Busan 604-714, Republic of Korea
2Medi-Farm Industrialization Research Center, Dong-A University, Busan 604-714, Republic of Korea
3Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University, Kyunggi-Do 440-746, Republic of Korea

Received 4 January 2013; Revised 29 March 2013; Accepted 7 April 2013

Academic Editor: Shrikant Anant

Copyright © 2013 Haw-Young Kwon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Spagnolo and P. Queirolo, “Upcoming strategies for the treatment of metastatic melanoma,” Archives for Dermatological Research, vol. 304, no. 3, pp. 177–184, 2012. View at Publisher · View at Google Scholar
  2. L. Finn, S. N. Markovic, and R. W. Joseph, “Therapy for metastatic melanoma: the past, present, and future,” BMC Medicine, vol. 10, no. 3, pp. 23–32, 2012. View at Publisher · View at Google Scholar
  3. S. Elmore, “Apoptosis: a review of programmed cell death,” Toxicologic Pathology, vol. 35, no. 4, pp. 495–516, 2007. View at Publisher · View at Google Scholar
  4. R. Kim, K. Tanabe, Y. Uchida, M. Emi, H. Inoue, and T. Toge, “Current status of the molecular mechanisms of anticancer drug-induced apoptosis: the contribution of molecular-level analysis to cancer chemotherapy,” Cancer Chemotherapy and Pharmacology, vol. 50, no. 5, pp. 343–352, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. S. H. Kaufmann and W. C. Earnshaw, “Induction of apoptosis by cancer chemotherapy,” Experimental Cell Research, vol. 256, no. 1, pp. 42–49, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. W. Tan, J. Lu, M. Huang et al., “Anti-cancer natural products isolated from chinese medicinal herbs,” Chinese Medicine, vol. 6, no. 7, pp. 27–42, 2011. View at Publisher · View at Google Scholar
  7. M. Gordaliza, “Natural products as leads to anticancer drugs,” Clinical and Translational Oncology, vol. 9, no. 12, pp. 767–776, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. B. J. Chen, “Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium Wilfordii Hook F,” Leukemia & Lymphoma, vol. 42, no. 3, pp. 253–265, 2001. View at Google Scholar · View at Scopus
  9. Q. Liu, “Triptolide and its expanding multiple pharmacological functions,” International Immunopharmacology, vol. 11, no. 3, pp. 377–383, 2011. View at Publisher · View at Google Scholar
  10. P. A. Phillips, V. Dudeja, J. A. McCarroll et al., “Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70,” Cancer Research, vol. 67, no. 19, pp. 9407–9416, 2007. View at Publisher · View at Google Scholar
  11. G. X. Zhou, X. L. Ding, J. F. Huang, H. Zhang, and S. B. Wu, “Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines,” Biochimica et Biophysica Acta, vol. 1770, no. 7, pp. 1021–1027, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. X. H. Jiang, B. C. Wong, M. C. Lin et al., “Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-κB activation in gastric cancer cells,” Oncogene, vol. 20, no. 55, pp. 8009–8018, 2001. View at Publisher · View at Google Scholar
  13. F. Zhao, Y. Chen, R. Li, Y. Liu, L. Wen, and C. Zhang, “Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro,” Toxicology, vol. 267, no. 1–3, pp. 70–79, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. G. S. Zhou, Z. Hu, H. T. Fang et al., “Biologic activity of triptolide in t(8,21) acute myeloid leukemia cells,” Leukemia Research, vol. 35, no. 2, pp. 214–218, 2011. View at Publisher · View at Google Scholar
  15. J. Lin, L. Y. Chen, Z. X. Lin, and M. L. Zhao, “The effect of triptolide on apoptosis of glioblastoma multiforme (GBM) cells,” Journal of International Medical Research, vol. 35, no. 5, pp. 637–643, 2007. View at Google Scholar · View at Scopus
  16. S. M. Johnson, X. Wang, and B. M. Evers, “Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors,” Journal of Surgical Research, vol. 168, no. 2, pp. 197–205, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. W. Zhu, H. Hu, P. Qiu, and G. Yan, “Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-κB-related mechanism,” Oncology Reports, vol. 22, no. 6, pp. 1397–1401, 2009. View at Google Scholar
  18. P. P. Wu, K. C. Liu, W. W. Huang et al., “Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway,” Oncology Reports, vol. 25, no. 2, pp. 551–557, 2011. View at Google Scholar
  19. Y. Tao, M. L. Zhang, P. C. Ma et al., “Triptolide inhibits proliferation and induces apoptosis of human melanoma A375 cells,” Asian Pacific Journal of Cancer Prevention, vol. 13, no. 4, pp. 1611–1615, 2012. View at Publisher · View at Google Scholar
  20. J. S. Baik, H. Y. Kwon, K. S. Kim, Y. K. Jeong, Y. S. Cho, and Y. C. Lee, “Cordycepin induces apoptosis in human neuroblastoma SK-N-BE(2)-C and melanoma SK-MEL-2 cells,” Indian Journal of Biochemistry & Biophysics, vol. 49, no. 2, pp. 86–91, 2012. View at Google Scholar
  21. K. M. Boatright and G. S. Salvesen, “Mechanisms of caspase activation,” Current Opinion in Cell Biology, vol. 15, no. 6, pp. 725–731, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. K. C. Zimmermann, C. Bonzon, and D. R. Green, “The machinery of programmed cell death,” Pharmacology & Therapeutics, vol. 92, no. 1, pp. 57–70, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Kim and E. L. Feldman, “Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt,” Journal of Biological Chemistry, vol. 277, no. 30, pp. 27393–27400, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. B. Kim, C. M. van Golen, and E. L. Feldman, “Degradationand dephosphorylation of focal adhesion kinase during Okadaic acid-induced apoptosis in human neuroblastoma cells,” Neoplasia, vol. 5, no. 5, pp. 405–416, 2003. View at Google Scholar · View at Scopus
  25. P. Kamarajan, J. Bunek, Y. Lin, G. Nunez, and Y. L. Kapila, “Receptor-interacting protein shuttles between cell death and survival signaling pathways,” Molecular Biology of the Cell, vol. 21, no. 3, pp. 481–488, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Huang, M. Khoe, M. Befekadu et al., “Focal adhesion kinase mediates cell survival via NF-κB and ERK signaling pathways,” American Journal of Physiology—Cell Physiology, vol. 292, no. 4, pp. C1339–C1352, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. L. P. Wen, J. A. Fahrni, S. Troie, J. L. Guan, K. Orth, and G. D. Rosen, “Cleavage of focal adhesion kinase by caspases during apoptosis,” Journal of Biological Chemistry, vol. 272, no. 41, pp. 26056–26061, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. F. G. Gervais, N. A. Thornberry, S. C. Ruffolo, D. W. Nicholson, and S. Roy, “Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide,” Journal of Biological Chemistry, vol. 273, no. 27, pp. 17102–17108, 1998. View at Publisher · View at Google Scholar · View at Scopus
  29. B. Simone, M. Ainhoa, T. Vicente et al., “Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis,” Cancer Research, vol. 69, no. 9, pp. 3755–3763, 2009. View at Publisher · View at Google Scholar
  30. H. Sasaki, F. Kotsuji, and B. K. Tsang, “Caspase 3-mediated focal adhesion kinase processing in human ovarian cancer cells: possible regulation by X-linked inhibitor of apoptosis protein,” Gynecologic Oncology, vol. 85, no. 2, pp. 339–350, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. M. S. Soengas and S. W. Lowe, “Apoptosis and melanoma chemoresistance,” Oncogene, vol. 22, no. 20, pp. 3138–3151, 2003. View at Publisher · View at Google Scholar
  32. J. A. Bush, K. J. J. Cheung Jr., and G. Li, “Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53,” Experimental Cell Research, vol. 271, no. 2, pp. 305–314, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. O. Micheau, E. Solary, A. Hammann, and M. T. Dimanche-Boitrel, “Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs,” Journal of Biological Chemistry, vol. 274, no. 12, pp. 7987–7992, 1999. View at Publisher · View at Google Scholar · View at Scopus
  34. R. G. Shao, C. X. Cao, W. Nieves-Neira, M. T. Dimanche-Boitrel, E. Solary, and Y. Pommier, “Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells,” Oncogene, vol. 20, no. 15, pp. 1852–1859, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. K. H. Chun, M. Pfahl, and R. Lotan, “Induction of apoptosis by the synthetic retinoid MX3350-1 through extrinsic and intrinsic pathways in head and neck squamous carcinoma cells,” Oncogene, vol. 24, no. 22, pp. 3669–3677, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Muller, S. Wilder, D. Bannasch et al., “p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs,” Journal of Experimental Medicine, vol. 188, no. 11, pp. 2033–2045, 1998. View at Publisher · View at Google Scholar
  37. G. W. McLean, N. O. Carragher, E. Avizienyte, J. Evans, V. G. Brunton, and M. C. Frame, “The role of focal-adhesion kinase in cancer—a new therapeutic opportunity,” Nature Reviews Cancer, vol. 5, no. 7, pp. 505–515, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. M. R. Hussein, A. K. Haemel, and G. S. Wood, “Apoptosis and melanoma: molecular mechanisms,” Journal of Pathology, vol. 199, no. 3, pp. 275–288, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. V. M. Golubovskaya, F. A. Kweh, and W. G. Cance, “Focal adhesion kinase and cancer,” Histology and Histopathology, vol. 24, no. 4, pp. 503–510, 2009. View at Google Scholar
  40. C. S. Smith, V. M. Golubovskaya, E. Peck et al., “Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines,” Melanoma Research, vol. 15, no. 5, pp. 357–362, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. J. Kabir, M. Lobo, and I. Zachary, “Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis,” Biochemical Journal, vol. 367, no. 1, pp. 145–155, 2002. View at Publisher · View at Google Scholar · View at Scopus
  42. J. C. Lee, C. Y. Tsai, J. Y. Kao et al., “Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells,” Molecular Nutrition & Food Research, vol. 52, no. 6, pp. 655–663, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. B. J. Tan, B. H. Tan, and G. N. Chiu, “Effect of triptolide on focal adhesion kinase and survival in MCF-7 breast cancer cells,” Oncology Reports, vol. 26, no. 5, pp. 1315–1321, 2011. View at Google Scholar
  44. E. Kurenova, L. H. Xu, X. Yang et al., “Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein,” Molecular and Cellular Biology, vol. 24, no. 10, pp. 4361–4371, 2004. View at Publisher · View at Google Scholar