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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 175135, 8 pages
Review Article

Emerging Roles of Propolis: Antioxidant, Cardioprotective, and Antiangiogenic Actions

1Department of Basic and Experimental Nutrition, Institute of Nutrition, State University of Rio de Janeiro, 20559-900 Rio de Janeiro, RJ, Brazil
2Department of Clinical and Toxicology Analysis, Faculty of Pharmaceutical Sciences, University of Sao Paulo, 05508-900 Sao Paulo, SP, Brazil

Received 15 January 2013; Revised 19 March 2013; Accepted 20 March 2013

Academic Editor: Vassya Bankova

Copyright © 2013 Julio Beltrame Daleprane and Dulcinéia Saes Abdalla. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Propolis has attracted attention in recent years due to its beneficial effects, which make it a potential preventive and therapeutic agent as well as a useful additive in food and cosmetics. The aim of this review is to discuss the growing evidence that propolis may, via a diverse array of biological actions, assist in the prevention of some inflammation-mediated pathologies including cardiovascular disease. The active components of propolis that have been identified so far include polyphenols and flavonoids. These compounds have cardioprotective, vasoprotective, antioxidant, antiatherosclerotic, anti-inflammatory and antiangiogenic actions. Many studies have been undertaken to elucidate the mechanism(s) by which propolis acts, which involve cellular signaling targets and interactions at the genomic level. This review will highlight the effects of propolis that may assist in the prevention of chronic degenerative diseases, such as cardiovascular disease.