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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 178067, 6 pages
http://dx.doi.org/10.1155/2013/178067
Research Article

Effects of Moxa Smoke on Monoamine Neurotransmitters in SAMP8 Mice

1School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China
2Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
3China & Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798
4Beijing Institute for Drug Control, Beijing 100035, China
5Center For Integrative Medicine, Department of Family and Community Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA

Received 21 January 2013; Revised 1 April 2013; Accepted 2 April 2013

Academic Editor: Lijun Bai

Copyright © 2013 Huanfang Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To investigate the anti-aging effects of moxa smoke on SAMP8 mice. Methods. Using factorial design, exposure length (15 or 30 minutes daily), and concentration (low, 5–15 mg/m3; middle, 25–35 mg/m3; high, 85–95 mg/m3), 70 SAMP8 mice were randomly assigned, /group, to a model group or one of six moxa smoke groups: L1, L2, M1, M2, H1, or H2. Ten SAMR1 mice were used as normal control. Mice in moxa smoke groups were exposed to moxa smoke at respective concentrations and exposure lengths; the model and normal control mice were not exposed. Cerebral 5-HT, DA, and NE levels were determined using ELISA. Results. Compared to normal control, the model group showed a significant decrease in 5-HT, DA, and NE. Compared to model group, 5-HT and NE were significantly higher in groups L2, M1, and M2 and DA was significantly so in L2 and M1. 5-HT, DA, and NE levels were the highest in group M1 among moxa smoke groups. A marked exposure length × concentration interaction was observed for 5-HT, DA, and NE. Conclusion. Moxa smoke increases monoamine neurotransmitter levels, which varies according to concentration and exposure length. Our finding suggests that the middle concentration of moxa smoke for 15 minutes seems the most beneficial.