Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in Rats

Table 2

Pharmacokinetic parameters of MDZ (10 mg/kg, i.v.) after treatment with a single dose of baicalin (0.225, 0.45 g/kg, i.v.) in rats.

	Control	Baicalin (0.225 g/kg)		Baicalin (0.45 g/kg)
	Value	Value	Ratio	Value	Ratio
𝐶max (mg/L)	6.5±1.0	7.0±1.4	1.10 (0.94 ~ 1.26)	7.3±1.9	1.15 (0.89 ~ 1.41)
𝑡1/2 (h)	0.44±0.08	0.51±0.18		0.51±0.16
V (L/kg)	3.6±0.7	3.0±1.0		3.1±1.4
CL (L/h/kg)	5.9±0.9	4.3±0.9^∗	0.75 (0.58 ~ 0.92)	4.2±0.8^∗∗	0.72 (0.58 ~ 0.87)
AUC0--𝑡 (mg·h/L)	1.7±0.2	2.3±0.7^∗	1.42 (1.01 ~ 1.84)	2.4±0.6^∗	1.44 (1.12 ~ 1.75)
AUC0--∞ (mg·h/L)	1.7±0.2	2.5±0.8^∗	1.47 (1.00 ~ 1.94)	2.5±0.6^∗∗	1.47 (1.15 ~ 1.79)

The results are means ± SD of 8-9 rats. Ratios are expressed as geometric mean ratio with 90% CI. Significance is indicated as *𝑃<0.05; **P < 0.01 compared to the control.