Combining Oxymatrine or Matrine with Lamivudine Increased Its Antireplication Effect against the Hepatitis B Virus In Vitro

Table 1

Clinical data of the combinational use of oxymatrine with 3TC for the treatment of HBV infection.

Data sources	Groups and dosages	Number of cases	Course of treatment (months)	Rate of ALT normalization (%)	Rate of HBeAg negative conversion (%)	Rate of HBV-DNA negative conversion (%)
Song [6]	3TC(100^#) + Omt(400)	32	3	78.1	46.9	90.6
	3TC(100)	30	3	50.0	16.7	86.7
Fan [7]	3TC(100) + Omt(400)	32	3	25	15	29
	3TC(100)	30	3	15	5	26
Duan [8]	3TC(100) + Omt(600)	60	6	—	53.3	63.3
	3TC(100)	60	6	—	18.3	23.3
Zhang [9]	3TC(100) + Omt(600)	62	6	—	53.23	62.90
	3TC(100)	62	6	—	19.35	24.19
Xie [10]	3TC(100) + Omt(150)	78	6	100	53.8	55.1
	3TC(100)	42	6	90.5	45.2	47.6
Liu [11]	3TC(100) + Omt(400)	31	12	100	61.3	87.1
	3TC(100)	34	12	100	37.1	85.7
Su [12]	3TC(100) + Omt(300^★)	30	12	91.23	66.67	86.67
	3TC(100)	30	12	68.26	43.33	63.33
Chen [13]	3TC(100) + Omt(200)	38	12	—	11	23
	3TC(100)	34	12	—	7	16

^#The dosage unit is mg/day.
^★The dosage of the former three months is 600 mg/day by intravenous administration, and the dosage of the followed nine months is 300 mg/day by oral administration.
—: the data were not reported in the original literatures.