Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 201643, 10 pages
http://dx.doi.org/10.1155/2013/201643
Research Article

An Aqueous-Ethanol Extract of Liriope spicata var. prolifera Ameliorates Diabetic Nephropathy through Suppression of Renal Inflammation

1Department of Food Science, College of Agriculture, National Pingtung University of Science and Technology, Neipu Township, Pingtung County 91201, Taiwan
2Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Township, Pingtung County 90701, Taiwan

Received 4 April 2013; Revised 27 June 2013; Accepted 12 July 2013

Academic Editor: Chun Tao Che

Copyright © 2013 Hung-Jen Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Ritz, X.-X. Zeng, and I. Rychlík, “Clinical manifestation and natural history of diabetic nephropathy,” Contributions to Nephrology, vol. 170, pp. 19–27, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. A. K. Lim and G. H. Tesch, “Inflammation in diabetic nephropathy,” Mediators of Inflammation, vol. 2012, Article ID 146154, 12 pages, 2012. View at Google Scholar
  3. J. Wada and H. Makino, “Inflammation and the pathogenesis of diabetic nephropathy,” Clinical Science, vol. 124, no. 3, pp. 139–152, 2013. View at Publisher · View at Google Scholar
  4. Z.-Y. Gao, J.-C. Zhang, H. Xu et al., “Analysis of relationships among syndrome, therapeutic treatment, and Chinese herbal medicine in patients with coronary artery disease based on complex networks,” Journal of Chinese Integrative Medicine, vol. 8, no. 3, pp. 238–243, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. W. Liu, Z. L. Wang, and H. Q. Liang, “Studies on the chemical constituents of Liriope spicata Lour (Thunb), var. prolifera Y.T. Ma,” Acta Pharmaceutica Sinica, vol. 24, no. 10, pp. 749–754, 1989. View at Google Scholar · View at Scopus
  6. Y. X. Zhu, L. Z. Liu, D. K. Ling, and W. Wang, “Chemical studies on the constituents of radix Ophiopogonis,” China Journal of Chinese Materia Medica, vol. 14, no. 6, pp. 359–383, 1989. View at Google Scholar · View at Scopus
  7. B.-Y. Yu, S.-X. Qiu, K. Zaw et al., “Steroidal glycosides from the subterranean parts of Liriope spicata var. prolifera,” Phytochemistry, vol. 43, no. 1, pp. 201–206, 1996. View at Publisher · View at Google Scholar · View at Scopus
  8. X. Chen, X. Bai, Y. Liu et al., “Anti-diabetic effects of water extract and crude polysaccharides from tuberous root of Liriope spicata var. prolifera in mice,” Journal of Ethnopharmacology, vol. 122, no. 2, pp. 205–209, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. X. Bai, X. Chen, Y. Liu et al., “Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice,” Journal of Ethnopharmacology, vol. 125, no. 3, pp. 482–486, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Christen and M. Cuendet, “Plants as a source of therapeutic and health products,” Chimia, vol. 66, no. 5, pp. 320–323, 2012. View at Publisher · View at Google Scholar
  11. D. Nguyen, F. Ping, W. Mu, P. Hill, R. C. Atkins, and S. J. Chadban, “Macrophage accumulation in human progressive diabetic nephropathy,” Nephrology, vol. 11, no. 3, pp. 226–231, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Chow, E. Ozols, D. J. Nikolic-Paterson, R. C. Atkins, and G. H. Tesch, “Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury,” Kidney International, vol. 65, no. 1, pp. 116–128, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. F. Y. Chow, D. J. Nikolic-Paterson, R. C. Atkins, and G. H. Tesch, “Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis,” Nephrology Dialysis Transplantation, vol. 19, no. 12, pp. 2987–2996, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Bagheri, A. Gol, S. Dabiri, and A. Javadi, “Preventive effect of garlic juice on renal reperfusion injury,” Iranian Journal of Kidney Diseases, vol. 5, no. 3, pp. 194–200, 2011. View at Google Scholar · View at Scopus
  15. V. Thallas-Bonke, S. R. Thorpe, M. T. Coughlan et al., “Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-α-dependent pathway,” Diabetes, vol. 57, no. 2, pp. 460–469, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. W. Shih, W. H. Hines, and E. G. Neilson, “Effect of cyclosporin A on the development of immune-mediated interstitial nephritis,” Kidney International, vol. 33, no. 6, pp. 1113–1118, 1988. View at Google Scholar · View at Scopus
  17. S. S. Ghosh, H. D. Massey, R. Krieg et al., “Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation,” American Journal of Physiology—Renal Physiology, vol. 296, no. 5, pp. F1146–F1157, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Furuta, T. Saito, T. Ootaka et al., “The role of macrophages in diabetic glomerulosclerosis,” American Journal of Kidney Diseases, vol. 21, no. 5, pp. 480–485, 1993. View at Google Scholar · View at Scopus
  19. J. G. M. C. Damoisequx, E. A. Dopp, W. Calame, D. Chao, G. G. MacPherson, and C. D. Dijkstra, “Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1,” Immunology, vol. 83, no. 1, pp. 140–147, 1994. View at Google Scholar · View at Scopus
  20. J. F. Navarro-González and C. Mora-Fernández, “The role of inflammatory cytokines in diabetic nephropathy,” Journal of the American Society of Nephrology, vol. 19, no. 3, pp. 433–442, 2008. View at Publisher · View at Google Scholar
  21. E. O. Long, “ICAM-1: getting a grip on leukocyte adhesion,” The Journal of Immunology, vol. 186, no. 9, pp. 5021–5023, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Fornoni, A. Ijaz, T. Tejada, and O. Lenz, “Role of inflammation in diabetic nephropathy,” Current Diabetes Reviews, vol. 4, no. 1, pp. 10–17, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Matsui, M. Suzuki, R. Tsukuda, K. Iida, M. Miyasaka, and H. Ikeda, “Expression of ICAM-1 on glomeruli is associated with progression of diabetic nephropathy in a genetically obese diabetic rat, Wistar fatty,” Diabetes Research and Clinical Practice, vol. 32, no. 1-2, pp. 1–9, 1996. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Sugimoto, K. Shikata, K. Hirata et al., “Increased expression of intercellular adhesion molecule-1 (ICAM-1) in diabetic rat glomeruli: glomerular hyperfiltration is a potential mechanism of ICAM-1 upregulation,” Diabetes, vol. 46, no. 12, pp. 2075–2081, 1997. View at Google Scholar · View at Scopus
  25. E. Galkina and K. Ley, “Leukocyte recruitment and vascular injury in diabetic nephropathy,” Journal of the American Society of Nephrology, vol. 17, no. 2, pp. 368–377, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Morii, H. Fujita, T. Narita et al., “Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropathy,” Journal of Diabetes and Its Complications, vol. 17, no. 1, pp. 11–15, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Gu, S. C. Tseng, and B. J. Rollins, “Monocyte chemoattractant protein-1,” Chemical Immunology, vol. 72, pp. 7–29, 1999. View at Google Scholar · View at Scopus
  28. C. Viedt and S. R. Orth, “Monocyte chemoattractant protein-1 (MCP-1) in the kidney: does it more than simply attract monocytes?” Nephrology Dialysis Transplantation, vol. 17, no. 12, pp. 2043–2047, 2002. View at Google Scholar · View at Scopus
  29. F. Y. Chow, D. J. Nikolic-Paterson, E. Ozols, R. C. Atkins, and G. H. Tesch, “Intercellular adhesion molecule-1 deficiency is protective against nephropathy in type 2 diabetic db/db mice,” Journal of the American Society of Nephrology, vol. 16, no. 6, pp. 1711–1722, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. C. Guijarro and J. Egido, “Transcription factor-κB (NF-κB) and renal disease,” Kidney International, vol. 59, no. 2, pp. 415–424, 2001. View at Publisher · View at Google Scholar · View at Scopus