Differences in Metabolites of Different Tongue Coatings in Patients with Chronic Hepatitis B
Table 3
Summary of metabolites revealed in this study.
Metabolites
Group A versus Group C (fold change)
value
Group B versus Group C (fold change)
value
Group A versus Group B (fold change)
value
Pathways
Butanedioic acid
+1.15
NS
−1.86*
0.043
+2.13##
0.008
Energy metabolism
Propanoic acid
−2.20*
0.02
−1.11
NS
−1.97#
0.025
Energy metabolism
Acetic acid
−1.02
NS
+1.65*
0.04
−1.68##
0.004
Flora metabolism
Ethanedioic acid
−2.24*
0.014
−2.32**
0.003
+1.03
NS
Energy metabolism
Butanoic acid
−1.18
NS
+1.36
NS
−1.60#
0.02
Flora metabolism
Glycine
+1.97*
0.039
+1.55
NS
+1.27
NS
Amino acid metabolism
2,3-Dihydroxybutanoic acid
+1.23
NS
+2.27*
0.047
−1.85#
0.032
Flora metabolism
Aminomalonic acid
−3.21**
0.002
−2.16*
0.017
+1.49
NS
Unknown
Cysteine
+2.11*
0.028
+2.40*
NS
+1.79#
0.04
Amino acid metabolism
Benzoic acid
+2.12*
0.016
+1.80*
0.029
−1.1
NS
Flora metabolism
D-Mannose
+1.71*
0.042
+1.48**
0.006
−1.93#
0.011
Energy metabolism
Sedoheptulose
+1.11
NS
+3.30*
0.038
−1.33
NS
Energy metabolism
D-Gluconic acid
−1.84*
0.016
+1.00
NS
−1.84#
0.01
Energy metabolism
Myo-inositol
−1.08
NS
+1.79*
0.042
−1.93##
0.0045
Energy metabolism
Tryptophan
+2.08*
0.016
+2.05*
0.035
+1.01
NS
Amino acid metabolism
Pseudouridine
+1.43
NS
+1.89*
0.033
−1.32
NS
Nucleotide metabolism
α-D-Glucopyranoside
−2.84*
0.033
−1.61
NS
−1.76
NS
Energy metabolism
“+” and “−” represent the relative increased (or decreased) concentration of metabolites; fold changes were obtained by calculating the relative concentration between the two group; *, ** compared with Group C (thin white coating); ##, # compared between Group A (thick yellow coating) and Group B (thick white coating); NS indicates nonsignificant; statistical significance (, unpaired Student’s -test).
