Electroacupuncture at 2/100 Hz Activates Antinociceptive Spinal Mechanisms Different from Those Activated by Electroacupuncture at 2 and 100 Hz in Responder Rats

Table 1

Summary of the changes produced by intrathecal drugs on the intensity (int) and duration (dur) of antinociception induced by electroacupuncture (EA) at different frequencies in the rat tail-flick test.

Drug	Dose	Sham	2-Hz EA		100-Hz EA		2/100-Hz EA
	μg	EA	int	dur	int	dur	int	dur
Desipramine	6	↑	—	—	—	—	—	—
	12	↑↑	—	—	—	—	—	—
Fluoxetine	6	↑	↓ ns	↑	—	↑	—	—
	12	↑↑	—	↑	—	↑↑	—	—
Thiorphan	16	↑	—	—	—	—	—	—
	32	↑↑	—	—	—	—	—	↑
Neostigmine	0.1	↑	—	↑	—	—	—	—
	0.2	↑	—	—	—	—	—	—
Gabapentin	150	—	—	↓	—	—	Block	↓ ↓
	300	↑	—	↓ ↓	—	—	—	—
Vigabatrin	0.3	↑	—	—	—	—	—	↑↑
	3.0	↑↑	—	—	—	—	—	↑

Abbreviations: —: no change; ↓: decrease; and ↑: increase (compared to saline-treated rats).