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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 213976, 4 pages
http://dx.doi.org/10.1155/2013/213976
Research Article

The Electrophysiological Effects of Qiliqiangxin on Cardiac Ventricular Myocytes of Rats

1Department of Cardiology, Shanghai Tenth People’s Hospital of Tongji University, 301 Yanchang Road, Shanghai 200072, China
2Department of Traditional Chinese Medicine, Shanghai Tenth People’s Hospital of Tongji University, 301 Yanchang Road, Shanghai 200072, China
3Zhengzhou Second People’s Hospital, 90 Hanghai Road, Zhengzhou, Henan 450015, China
4Department of Cardiology, General Hospital of Beijing Military Command, No. 5 Nanmencang, Dongsishitiao, Dongcheng District, Beijing 100007, China

Received 2 May 2013; Revised 24 June 2013; Accepted 2 July 2013

Academic Editor: Hao Xu

Copyright © 2013 Yidong Wei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Qiliqiangxin, a Chinese herb, represents the affection in Ca channel function of cardiac myocytes. It is unknown whether Qiliqiangxin has an effect on Na current and K current because the pharmacological actions of this herb’s compound are very complex. We investigated the rational usage of Qiliqiangxin on cardiac ventricular myocytes of rats. Ventricular myocytes were exposed acutely to 1, 10, and 50 mg/L Qiliqiangxin, and whole cell patch-clamp technique was used to study the acute effects of Qiliqiangxin on Sodium current ( ), outward currents delayed rectifier outward K+ current ( ), slowly activating delayed rectifier outward K+ current ( ), transient outward K+ current ( ), and inward rectifier K+ current ( ). Qiliqiangxin can decrease by , and its IC50 was 9.2 mg/L. 10 and 50 mg/L Qiliqiangxin decreased by and summit current density of . 10 and 50 mg/L Qiliqiangxin decreased by and . Qiliqiangxin represented a multifaceted pharmacological profile. The effects of Qiliqiangxin on Na and K currents of ventricular myocytes were more profitable in antiarrhythmic therapy in the clinic. We concluded that the relative efficacy of Qiliqiangxin was another choice for the existing antiarrhythmic therapy.