Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Fig 5

Research Article

Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway

Figure 5

Effect of GTE on the growth of SKOV-3 xenografted tumors in vivo. (a) Tumor growth rate was significantly slower in the GTE-treated group (200 mg/kg/day, ; or 1,000 mg/kg/day, ) versus the control group ( ). The tumor volumes were estimated from the caliper measurements of three dimensions of the tumor. The estimated tumor volumes were calculated as , where is the major axis and is tumor width. The results are represented as the mean ± SD. (b) The body weight of nude mice was not significantly different between the control and GTE-treated groups. (c) Downregulation of Ki-67, HER2, and cyclin D1 expression by GTE in SKOV-3 xenografted tumors on nude mice. The IHC analysis was performed on SKOV-3-induced xenografted tumors. The two representative specimens appear to show that GTE-treated mice (200 mg/kg/day) have lower protein expression than vehicle controls, for Ki-67, HER2, and cyclin D1 (400X magnification).

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