Cardiovascular Effects of Salvianolic Acid B

Table 10

Preventing cell migration, proliferation, and intimal hyperplasia salvianolic acid B in vitro.

Cells/tissues	Effects	Reference
rVSMCs	PDGF signaling pathway,; scavenge ROS,; system of xanthine oxidase,; generation of ROS,; process of neointimal,; prevent proliferation,; prevent migration.	Hur et al., 2008 [68]
A10	Expression of SDF-1α/CXCR4,; regulate Raf-1 and MEK,; regulate ERK1/2 and phosphorylation ERK1/2,; regulate FAK and phosphorylated FAK,; activity of NF-κB promoter.	Pan et al., 2012 [69]
Human mesangial cells	Modulate the cell-cycle progress,; activity of MMP-2,; activity of MMP-9,; suppress NF-κB activation.	Luo et al., 2008 [70]

Note: ROS: reactive oxygen species; MMP-2: matrix metalloproteinase-2; MMP-9: matrix metalloproteinase-9; PDGF: platelet-derived growth factor; A10 cells: vascular smooth muscle cells.