Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 11 / Review Article
Cardiovascular Effects of Salvianolic Acid B Table 11 Antiatherosclerosis of salvianolic acid B in vitro.
Cells/tissues Effects Reference VSMCs Nrf2-ARE signaling pathway, activation of NQO1.
Hur et al., 2010 [71 ] H-monDC Supress activation of PPARγ nuclear translocation, expression of CD40, CD86, CD1a, and HLA-DR, expression of IL-12 and IL-10, production of TNF-α , regulation of TLR4, myeloid differentiation of primary reactive protein 88, p38-MAPK signaling pathway.
Sun et al., 2011 [72 ] Macrophage Reduce mLDL uptake, antagonize CD36.
Bao et al., 2012 [73 ] HASMCs MMPs protein synthesis, downregulate ERK1/2, downregulate c-JNK.
Lin et al., 2007 [74 ]
Note: H-monDC: human monocyte-derived dendritic cells; Nrf2: nuclear factor 2-related factor 2; NQO1: NAD(P)H quinine oxidoreductase-1; PARP: poly ADP-ribose polymerase; ARE: antioxidant responsive element; VSMC: vascular smooth muscle cells; IL: interleukin; TLR: toll like receptor; TNF: tumor necrosis factor.