Catechins and Sialic Acid Attenuate Helicobacter pylori-Triggered Epithelial Caspase-1 Activity and Eradicate Helicobacter pylori Infection
Figure 6
Hematoxylin and eosin staining (H&E) of infiltrated leukocytes (IL; arrows in a2) and immunohistochemical staining of CD68, caspase-1, IL-1β, TUNEL, and Beclin-1 in the mouse gastric mucosa (×200 magnification; length of axis, 480 μm). (a1, b1, c1, d1, e1, and f1) Uninfected control mice; (a2, b2, c2, d2, e2, and f2) H. pylori-infected mice; and (a3, b3, c3, d3, e3, f3) catechins and sialic acid (CS) treated H. pylori-infected mice. Arrows indicate positive staining for CD68, caspase-1, IL-1β, TUNEL, and Beclin-1 (brown color). Statistical data are presented in (a4, b4, c4, d4, e4, and f4). Each column with a vertical line represents mean ± SEM. , compared to the untreated uninfected control (Control); , H. pylori infection plus CASA (HP + CS) versus H. pylori infection (HP).
