Catechins and Sialic Acid Attenuate Helicobacter pylori-Triggered Epithelial Caspase-1 Activity and Eradicate Helicobacter pylori Infection

Figure 7

A proposed mechanism by which catechins and sialic acid suppress H. pylori-triggered caspase-1 signaling. First, on the luminal surface, catechins and sialic acid decrease the H. pylori density via their antibacterial and antiadhesive properties. Second, catechins and sialic acid are powerful antioxidants that are able to suppress the production of CD68 and NADPH oxidase gp91phox-derived ROS, both of which may induce apoptosis and caspase-1 activation during H. pylori infection. In addition, catechins and sialic acid also enhance autophagy, thereby decreasing caspase-1 activation and IL-1β secretion.