Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Fig 6

Research Article

Blockade of Airway Inflammation by Kaempferol via Disturbing Tyk-STAT Signaling in Airway Epithelial Cells and in Asthmatic Mice

Figure 6

Time course response of STAT3 (a), suppression of STAT1/3 phosphorylation (b), and elevation of SOCS-3 expression (c) by kaempferol in LPS-stimulated BEAS-2B cells. BEAS-2B cells were treated with 1–20 μM kaempferol in the absence and presence of 2 μg/mL LPS for 8 h. For western blot analysis, total cell protein extracts were immunoblotted with a primary antibody against phosphorylated STAT1, phosphorylated STAT3, total STAT3, SOCS-3, or β-actin as an internal control. The bar graphs (mean SEM, ) in the bottom panels represent quantitative densitometric results. Means without a common letter differ, .

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