Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network

Table 1

The general network topology analysis on the withdrawn drug-target network and the approved drug-target network by Cytoscape.

Topology properties	Withdrawn drug-target network	Approved drug-target network
Clustering coefficient	0.0	0.0
Connected components	44	217
Network diameter	7	23
Network radius	1	1
Network centralization	0.107	0.054
Shortest paths	2902	5673774
Characteristic path length	2.914	7.510
Avg. number of neighbors	1.849	3.801
Number of nodes	172	2889
Number of drug nodes	66	1411
Network density	0.011	0.001
Network heterogeneity	1.345	1.874
Isolated nodes	23 (34.85%)	131 (9.28%)
Number of self-loops	0	0
Multiedge node pairs	0	0