In Vitro Morphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes of Curcuma zedoaria

Table 2

Cytotoxic activity (IC₅₀ values (μg/mL)) of isolated compounds against selected human cancer cell lines.

Compounds	IC50 (μg/mL)
	MCF-7	Ca Ski	HCT-116	MRC-5
Curzerenone (1)	40.0±0.5	8.9±0.7	53.0±1.5	20.0±1.2
Neocurdione (2)	53.5±1.1	46.2±1.1	64.0±1.3	59.0±0.4
Zederone (5)	>100.0	>100.0	>100.0	>100.0
Alismol (4)	10.0±0.7	8.70±1.1	9.0±0.9	>100.0
Sterols (6–8)	>100.0	>100.0	>100.0	>100.0
*Doxorubicin	0.05±0.01	0.18±0.06	0.24±0.04	0.40±0.03

∗Doxorubicin was used as the positive reference compound. Tabulated values are mean ± standard deviation (SD) of three replicates.