The Effects of Acupuncture on Bladder Interstitial Cells of Cajal Excitability in Rats with Overactive Bladder

Figure 7

The quantity of HCN2 channel in bladder ICCs. ((a), (b), (c), and (d)) Double-labeled immunofluorescence of HCN2 and c-Kit in bladder. Nucleus stained by DAPI (blue), c-Kit (green), and HCN2 (red) staining in urothelium, suburothelium, and muscle layer. Some ICCs were c-kit positive (↑), some were HCN2 positive (◆), and some were double labeled (▲). (a) Normal control group, (b) model group, (c) acupuncture group, (d) Glivec group. Scale bar is 50 μm. (e) Comparisons of relative quantity of HCN2 channel in bladder ICCs after treatment. * versus normal control group 𝑃<0.05. △ versus model group 𝑃<0.05.

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