Research Article
Pharmacometrics of 3-Methoxypterostilbene: A Component of Traditional Chinese Medicinal Plants
Table 1
Pharmacokinetic parameters of 3-methoxypterostilbene in the rat.
| | Pharmacokinetic parameter | Intravenous
Mean ± SEM | Oral
Mean ± SEM |
| | AUCinf (µg·h/mL) | 48.1 ± 23.8 | 229 ± 44.6 | | Vdβ (L/kg) | 5.11 ± 0.380 | 52.0 ± 10.5 | | CLhepatic (L/h/kg) | 47.1 ± 23.3 | 0.480 ± 0.0800 | | CLrenal (L/h/kg) | 0.760 ± 0.460 | 0.0100 ± 0.000 | | CLtotal (L/h/kg) | 47.8 ± 23.7 | 0.480 ± 0.0800 | |
(%) | 1.64 ± 0.950 | 1.24 ± 0.160 | | (h) serum | 18.9 ± 10.9 | 73.3 ± 8.91 | | (h) urine | 9.54 ± 1.51 | 20.6 ± 3.01 | | MRT (h) | 26.0 ± 15.0 | 105 ± 13.1 | | Bioavailability (F%) | 100 | 50.6 ± 10.0 |
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