Evidence-Based Complementary and Alternative Medicine

Review Article

Chinese Herbal Medicine Qi Ju Di Huang Wan for the Treatment of Essential Hypertension: A Systematic Review of Randomized Controlled Trials

Table 1

Characteristics and methodological quality of included studies.


Study ID	Sample	Diagnosis standard	Intervention	Control	Course (week)	Outcome measure

Li et al., 2012 [21]	120	1999 WHO-ISH GMH; GCRNDTCM	QJDHW	Captopril	8	BP; TCM-SSD; BL; PV; side effect
Zhu, 2012 [22]	92	CGPMHBP-2005	QJDH pill plus nifedipine controlled release tablet	Nifedipine controlled release tablet	8	BP
Du et al., 2009 [23]	120	JNC-7; GCRNDTCM	QJDH pill plus felodipine (plendil)	Felodipine (plendil)	4	BP; TCM-SSD; Ang II,ET, CGRP
Yang and Cheng, 2005 [24]	120	Hypertension diagnostic criteria (unclear)	modified QJDHW plus metoprolol	Metoprolol	8	BP
OuYang, 2002 [25]	102	Hypertension diagnostic criteria (unclear); TCM diagnostic criteria (unclear)	QJDH pill plus verapamil	Verapamil	8	BP; TCM-SSD; BL
Zhang, 1999 [26]	70	1999 WHO-ISH GMH; GCRNDTCM	QJDH pill	Nifedipine	8	BP
Ling, 2011 [27]	60	Hypertension diagnostic criteria (unclear)	QJDH pill	Captopril	4	BP
Liu, 2008 [28]	180	CGPMHBP-2000	QJDH pill plus Western drugs	Western drugs	24	BP
Zhong, 2006 [29]	80	Hypertension diagnostic criteria (unclear)	QJDH pill plus antihypertensive tablets	Antihypertensive tablets	4	BP
Zhou, 2002 [30]	80	Hypertension diagnostic criteria (unclear)	QJDH pill	Nifedipine controlled release tablet	4	BP

Abbreviations: QJDHW: Qi Ju Di Huang Wan; WHO-ISH GMH: WHO-ISH guidelines for the management of hypertension; GCRNDTCM: Guidelines of Clinical Research of New Drugs of Traditional Chinese Medicine; CGPMHBP: China Guidelines on Prevention and Management of High Blood Pressure; JNC-7: Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; TCM: traditional Chinese medicine; TCM-SSD: TCM syndrome and symptom differentiation; BP: blood pressure; BL: blood lipid; PV: plasma viscosity; Ang II: angiotensin II; ET: endothelin; CGRP: calcitonin gene-related peptide.